BJUI Mini Reviews - The sensitivity of fluorescent-light cystoscopy for the detection of carcinoma in situ (CIS) of the bladder: A meta-analysis with comments on gold standard

BERKELEY, CA (UroToday.com) - The purpose of this review was to examine evidence on the sensitivity of fluorescentlight cystoscopy (FLC; alternative term photodynamic diagnosis) for urothelial carcinoma in situ (CIS) of the bladder, and to offer a discussion from a histopathology standpoint.

Attention was called to the absence of a ‘gold standard’ in FLC sensitivity analyses in a 1999 publication by Schneeweiss et al.[ 1 ] entitled ‘Is everything all right if nothing seems wrong’? Recent FLC research reports and systematic reviews do not clearly address this issue. A statement in a FLC publication by Jeon et al.[ 2 ] exemplifies the hazard of claiming that all CIS are detected by a combination of FLC and white-light cystoscopy (WLC): ‘no CIS went undetected.’ Happily though, a recent study by Gudjónsson et al.[ 3 ] that examined the diagnostic performance of five-biopsy bladder mapping did use cystectomy specimens as gold standard...View or save the full text Mini Review as a .pdf file

 


Björn L. Isfoss

Department of Pathology, Telemark Hospital, Skien, Norway

 



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