Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8100, Room 5026, St Louis, MO 63110, USA.
We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members.
We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls.
Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (≥40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P< 0.0001, 0.021, and 0.92, respectively).
Chlamydia and gonorrhoea may infect the prostate of some infected men.
Written by:
Sutcliffe S, Nevin RL, Pakpahan R, Elliott DJ, Cole SR, De Marzo AM, Gaydos CA, Isaacs WB, Nelson WG, Sokoll LJ, Zenilman JM, Cersovsky SB, Platz EA. Are you the author?
Reference: Br J Cancer. 2011 Jul 26. Epub ahead of print.
doi: 10.1038/bjc.2011.271
PubMed Abstract
PMID: 21792196
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