BACKGROUND: The present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean®) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL).
METHODS: This was a single center, observational, prospective study in a total of 20 women (mean age 35.2 years; 50.0% were married). Patients were followed up for 3 and 6 months during treatment.
RESULTS: The number of PCUTIs in the previous 3 months prior to start the treatment with Cysticlean® was 2.8+/-1.3 and it was reduced to 0.2+/-0.5 at Month 6 (P< 0.0001), which represent a 93% improvement. At baseline, the mean score on the VAS scale (range from 0 to 100) for assessing the QoL was 62.4+/-19.1, increasing to 78.2+/-12.4 at Month 6 (P=0.0002), which represents a 20% improvement. All patients had an infection with positive urine culture at baseline, after 6 months there were only 3 symptomatic infections (P< 0.001). The most common bacterium was Escherichia coli.
CONCLUSIONS: Prophylaxis with American cranberry extract (Cysticlean®) could be an alternative to classical therapies with antibiotics. Further studies are needed to confirm results obtained in this pilot study.
Written by:
Ballester FS, Vidal VR, López Alcina E, Domenech Perez C, Escudero Fontano E, Oltra Benavent AM, Montoliu García A, Sobrón Bustamante MA. Are you the author?
Urodynamics Unit, Hospital Quirón, Avenida de Vicente Blasco Ibañez 14, 46010, Valencia, Spain.
Reference: BMC Urol. 2013 Jun 5;13(1):28.
doi: 10.1186/1471-2490-13-28
PubMed Abstract
PMID: 23738867
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