INTRODUCTION: This study evaluated the clinical factors that influence bladder capacity and lower urinary tract dysfunction (LUTD) following kidney transplantation (KT) in end-stage renal disease (ESRD) patients.
MATERIALS AND METHODS: Data were analyzed in ESRD patients who underwent KT between January 2011 and January 2013. The analyzed pre-KT parameters include bladder capacity, vesicoureteral reflux (VUR), postvoid residual urine (PVR), micturition frequency, and voiding volume. Associations between pre-KT parameters, small bladder capacity (< 100 cc), and parameters that influence the development of LUTD were also evaluated. LUTD after KT was defined as voiding symptoms that lasted >1 month and required specific treatment.
RESULTS: In total, 622 ESRD patients required KT. The mean age and dialysis duration were 43.9 ± 11.2 years and 59.4 ± 60.7 months. The mean bladder capacity before KT was 300.1 ± 149.8 mL, and 14 % of patients were diagnosed with small bladder capacity. VUR and PVR were observed in 110 (17.5 %) and 83 (13.6 %) patients. Factors associated with small bladder capacity included long-term dialysis, presence of VUR, and PVR (p < 0.001, p = 0.004, p = 0.003). After KT, 31 patients (4.9 %) needed treatment due to LUTD. Factors associated with the development of LUTD included age, VUR, and PVR (p = 0.001 p = 0.034, p < 0.001). Bladder capacity did not affect LUTD after KT.
CONCLUSION: ESRD patients on long-term dialysis will likely have small bladder capacity and VUR; however, bladder capacity itself is not related to the occurrence of LUTD after KT.
Written by:
Song M, Park J, Kim YH, Han DJ, Song SH, Choo MS, Hong B. Are you the author?
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 138-736, Korea.
Reference: Int Urol Nephrol. 2014 Sep 28. Epub ahead of print.
doi: 10.1007/s11255-014-0848-1
PubMed Abstract
PMID: 25262149