Several studies have reported beneficial cardiovascular effects of marine n-3 polyunsaturated fatty acids. To date, no large studies have investigated the potential benefits of marine n-3 polyunsaturated fatty acids in recipients of renal transplants.
In this observational cohort study of 1990 Norwegian recipients of renal transplants transplanted between 1999 and 2011, associations between marine n-3 polyunsaturated fatty acid levels and mortality were investigated by stratified analysis and multivariable Cox proportional hazard regression analysis adjusting for traditional and transplant-specific mortality risk factors Marine n-3 polyunsaturated fatty acid levels in plasma phospholipids were measured by gas chromatography in a stable phase 10 weeks after transplantation
There were 406 deaths (20 4%) during a median follow-up period of 6 8 years Mortality rates were lower in patients with high marine n-3 polyunsaturated fatty acid levels (≥7 95 weight percentage) compared with low levels (
Higher plasma phospholipid marine n-3 polyunsaturated fatty acid levels were independently associated with better patient survival
Clinical journal of the American Society of Nephrology : CJASN 2015 Jun 10 [Epub]
Ivar A Eide, Trond Jenssen, Anders Hartmann, Lien M Diep, Dag O Dahle, Anna V Reisæter, Kristian S Bjerve, Jeppe H Christensen, Erik B Schmidt, My Svensson
Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; ivaeid@ous-hf no , Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; Metabolic and Renal Research Group, University of Tromsø The Arctic University of Norway, Tromsø, Norway;, Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, The University of Oslo, Oslo, Norway;, Department of Biostatistics, Epidemiology and Health Care Economics, Oslo University Hospital, Oslo, Norway;, Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway;, Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; The Norwegian Renal Registry, Oslo University Hospital, Rikshospitalet, Oslo, Norway;, Department of Medical Biochemistry, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; and , Departments of Nephrology and , Cardiology, Aalborg University Hospital, Aalborg, Denmark; and , Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark