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- Sarah Amend discusses research on polyaneuploid cancer cells (PACCs) and their role in metastasis, published in Molecular Cancer Research. Dr. Amend explains how cancer cells under stress enter an adaptive endocycling state, increasing dramatically in size and genomic content without dividing. The discussion highlights their findings that cells in the PACC state are preferentially found in circula...
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- Neeraj Agarwal leads a discussion with Martin Schoen and Bruce Montgomery about a study examining treatment patterns and outcomes for veterans with metastatic hormone-sensitive prostate cancer. The research reveals that VA patients demonstrate longer survival rates compared to the general U.S. population, particularly among younger patients, with combination therapy now being utilized in approxima...
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- Andrea Miyahira interviews Hala Borno about Trial Library, an innovative platform developed to improve access to clinical trials and increase diversity in trial participation. The technology-enabled service connects community providers with clinical trials while offering comprehensive patient navigation support, addressing social determinants of health and practical barriers to trial participation...
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- Oliver Sartor and Kambiz Rahbar discuss the RaLu study examining the safety and efficacy of sequential radiopharmaceutical treatments in metastatic castration-resistant prostate cancer. The discussion highlights how lutetium-PSMA therapy can be safely administered following radium treatment, with outcomes consistent across different treatment sequences and timing intervals. They examine how these...
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- Oliver Sartor and Wolfgang Fendler explore the evolving role of PSMA PET imaging in assessing treatment response and progression in prostate cancer. Dr. Fendler outlines two key assessment approaches: the PPP criteria for early-stage disease focusing on lesion numbers, and the RECIP criteria for advanced disease examining tumor volume changes. The conversation highlights how PSMA PET findings corr...
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- Amy Pearlman discusses penile traction therapy using the RestoreX device, a second-generation technology designed to address penile length changes after prostate cancer treatment. Dr. Pearlman explains how this device, developed by Dr. Landon Trost at Mayo Clinic, offers advantages over first-generation devices through its dynamic stretching capabilities and shorter required usage times. The discu...
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- Amy Pearlman discusses penile rehabilitation strategies following prostate cancer treatment. Dr. Pearlman shares her expertise on vacuum pump therapy as a crucial component of penile rehabilitation. The discussion emphasizes the importance of early intervention and ongoing maintenance to preserve penile health, comparing the penis to a sponge that requires regular blood flow to maintain its struct...
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- Samir Zaidi joins Andrea Miyahira to discuss a paper on single-cell analysis of treatment-resistant prostate cancer. Using advanced single-cell technologies, the study reveals significant diversification in gene programs within castrate-resistant prostate cancer, identifying multiple tumor states and transcription factor networks that emerge as resistance mechanisms to androgen receptor signaling...
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- Michael Rabow joins Ruchika Talwar to discuss the benefits of early palliative care intervention in prostate cancer patients. Dr. Rabow highlights four key advantages: improved patient and caregiver satisfaction, better symptom management, enhanced care efficiency with reduced costs, and potential life prolongation. He references a landmark 2010 study showing nearly three months increased survival...
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- At the 2024 LUGPA annual meeting, Scott Eggener reviews cutting-edge prostate cancer technologies, from screening and imaging to genomic testing and emerging treatments. He provides balanced perspectives on new innovations, emphasizing evidence-based adoption and cautioning against unproven expensive technologies. Biographies: Scott Eggener, Professor of Surgery (Urologic Oncology) and Radiology,...
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