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- Anne Schuckman, MD, MBBS, discusses which patients with high-risk non-muscle-invasive bladder cancer may benefit from radical cystectomy with Ashish Kamat, MD. What’s clinically difficult in high-risk non-muscle-invasive bladder cancer is that 50% of patients undergoing TURBT plus intravesical therapy have long-term recurrence-free survival, however, 20% will progress to muscle-invasive bladder ca...
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- In this conversation with Ashish Kamat, Lars Dyrskjøt, an expert in the field of molecular markers and personalized medicine speaks about circulating tumor DNA and the potential as a tumor for guiding treatment decisions in bladder cancer. Cell-free DNA in the blood has a half-life of less than two hours, so it makes it possible to use it as a biomarker of the direct tumor burden and hence the det...
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- Bernard Bochner joins Ashish Kamat in this discussion discussing the advancements throughout 2020 in muscle-invasive non-metastatic bladder cancer. It would be impossible to discuss the year without mentioning the impact of COVID-19. There are some diseases that can withstand treatment delay, but muscle-invasive bladder cancer is not one of those tumors. These challenges pushed the bladder cancer...
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- Management decisions at presentation are critical for survival— a talk by Curtis A Pettaway, MD. Although primary urethral carcinoma (UC) is rare, with an incidence of 4.3 per million in men and 1.5 per million in women, recurrence is associated with distant metastases. Therefore, physicians will want to be alert to the possibility of UC when, for example, the patient has a urethral protrusion. Th...
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- The Phase 3 data from the United States clinical trial evaluating an investigational gene therapy, nadofaragene firadenovec (rAd-IFN/Syn3), for the treatment of patients with high-grade, Bacillus Calmette-Guérin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC) was recently published in The Lancet Oncology. In this conversation with Dr. Ashish Kamat, Girish Kulkarni, MD discusses the k...
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- In this conversation with Ashish Kamat, MD, Arjun Balar, MD, MBBS, discusses testing the concept of effectively treating bladder cancer without needing chemotherapy in the non-muscle-invasive disease space, specifically patients with high-risk carcinoma in situ, with or without papillary tumors that had become unresponsive to Bacillus Calmette-Guerin (BCG) based on the current Federal Drug Adminis...
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- Ashish Kamat welcomes Karen Sachse, a patient advocate for the Bladder Cancer Advocacy Network (BCAN) who shares her perspective on non muscle-invasive bladder cancer, the various trials that are ongoing, and the future of various studies. As a bladder cancer survivor diagnosed in 2010 at age 54 with high grade non-muscle invasive bladder cancer, she is disease-free since 2014. Biographies: Karen...
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- Co-chair of the Bacillus Calmette Guerin (BCG)-unresponsive non-muscle-invasive bladder cancer session during the 2020 Virtual Bladder Cancer Advocacy Network Think Tank (BCANTT) meeting, Peter Black, MD joins Ashish Kamat, MD, MBBS providing a succinct overview of this session highlighting the clinical and the translational panel which addresses defining treatment failure after BCG treatment for...
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- Param Mariappan, MBBS, FRCS(Urol), PhD, and Prashant Patel, MBBS, MS, FRCSEd, FRCSEd (Urol), PhD, join Ashish Kamat, MD, MBBS, and discuss transurethral resection of bladder tumor (TURBT). Dr. Mariappan begins by explaining the importance of quality indicators for TURBT. He emphasizes the importance of having a comprehensive checklist of quality indicators. Dr. Patel discusses the current challeng...
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- Eva Comperat and Hikmat Al-Ahmadie, MD, join Ashish Kamat, MD, MBBS to challenge the use of immunohistochemistry, or traditional pathology, versus molecular subtyping in bladder cancer. Dr. Comperat discusses immunohistochemistry, explaining it is more precise, and because it is standardized and more widely used than molecular subtyping, it remains the gold standard. Dr. Al-Ahmadie continues by de...
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