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- Daniel Spratt, MD, reviews the data from two trials that demonstrate the selection of patients for the addition of hormone therapy (ADT) to post-prostatectomy radiation therapy. Dr. Spratt discusses two phase three trials that have evaluated hormonal therapy in the postoperative RP setting with a rising PSA. The RTOG 9601 trial and the GETUG-AFU 16 trial are distinct from each other where the RTOG...
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- Ashley Ross, MD, PhD, Alan Dal Pra, MD, and Daniel Spratt, MD, discuss two cases of patients each about 18 months post-prostatectomy with rising PSA, evaluating the timing to radiotherapy and the evidence to intensify with ADT. Biographies: Ashley Ross, MD, Ph.D., Associate Professor, Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois Alan Dal Pra, MD, A...
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- In this conversation, Mathew Cooperberg and Stacy Loeb discuss recent advances in prostate cancer screening and shared decision making in the Veterans Health Administration (VA). Dr. Loeb highlights findings from a Journal of the National Cancer Institute publication looking at trends of PSA screening in the VA healthcare system and which found a decline in the use of PSA testing among PSA eligibl...
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- When we think about prostate cancer health disparities, particularly there are two main areas of importance, understanding what the effects are and also figuring out what the implementation strategies could be. In this conversation with Alicia Morgans, Director of Radiation Oncology at the Moffitt Cancer Center, Kosj Yamoah highlights the currently enrolling VANDAAM Study, a prospective study vali...
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- M Minhaj Siddiqui joins Matthew Cooperberg to highlight the Patient-Centered Outcomes Research Institute (PCORI) grant awarded to researchers at the University of Maryland School of Medicine (UMSOM). The grant supports the initiative to highlight, to a greater extent, the patient's voice in determining the next course of action to chart in the future of active surveillance in the United States. Mo...
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- Ruth Etzioni, PhD joins Matthew Cooperberg, MD MPH in a discussion about the role and history of prostate cancer modeling based upon PSA. Cancer Intervention and Surveillance Modeling Network (CISNET) is a consortium of NCI-sponsored investigators who use simulation modeling to improve our understanding of cancer control interventions in prevention, screening, and treatment and their effects on po...
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- Alicia Morgans and Ashley Ross delve into the use of relugolix in radiation settings for prostate cancer. They explore the drug's advantages, including rapid testosterone recovery and fewer cardiovascular side effects, making it a viable option for patients with intermediate to high-risk localized disease. Dr. Ross emphasizes the drug's utility in the "early salvage space," particularly for patien...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen provide insights into the JAMA Oncology publication titled Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial. The management of patients with localized and recurrent prostate cancer is driven predominantly at this point by cli...
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- A recent systematic review assessed the clinical utility of the Decipher® genomic classifier. This genomic classifier assesses 22 genes representing multiple oncologic pathways and is independently prognostic of oncologic outcomes. During the 2021 ASCO GU Cancers Symposium, Ashley Ross, MD, PhD, highlighted this review and presented on the use of genomics to guide treatment decisions in post-prost...
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- Ashley Ross is joined by Daniel Spratt presenting a European Association of Urology publication on A Systematic Review of the Evidence for the Decipher Genomic Classifier in Prostate Cancer . In a field of rapidly acquiring data, among the challenges that motivated this systematic review was the breadth of papers and data being published. Dr. Spratt and colleagues sought to acquire the most up-to-...
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