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- Alicia Morgans converses with Scott Tagawa about patient-reported outcomes in men undergoing PSMA targeted radiopharmaceutical treatments for prostate cancer. The discussion centers on a Department of Defense-funded study that aims to develop a new patient-reported outcome tool specifically for this patient population. Dr. Tagawa elaborates on the instruments commonly used in clinical trials, such...
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- Alicia Morgans, MD, MPH, is joined by Michael Morris, MD, to discuss the phase III VISION trial results and the practice-changing implications when lutetium-177-PSMA-617 is FDA approved. The VISION trial evaluated men who had post androgen receptor pathway inhibitor therapy and post docetaxel or docetaxel and cabazitaxel chemotherapy, who were randomized to a protocol-defined standard of care with...
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- Oliver Sartor, MD, joins Charles Ryan, MD in a conversation about the New England Journal of Medicine publication "Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer" known as the VISION trial. The VISION Trial is an international, open-label, phase 3 trial evaluating 177Lu-PSMA-617 in patients who had metastatic castration-resistant prostate cancer previously treated with a...
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- In this conversation, Scott Tagawa and Oliver Sartor join Charles Ryan in a discussion on the PSMAddition clinical trial that integrates lutetium-177 with standard-of-care therapy in metastatic castration-sensitive prostate cancer (mCSPC). The trial aims to determine the efficacy and safety of lutetium-177 administered earlier in the disease course. They believe that using lutetium-177 upfront wil...
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- Oliver Sartor, MD, the CO-PI on the VISION Trial joins Alicia Morgans, MD, MPH in a conversation on the practice-changing VISION Trial results presented at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting. 177Lu-PSMA-617 is a targeted radioligand therapy that delivers ß-particle radiation to PSMA-expressing cells and the surrounding microenvironment. The VISION study was an int...
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- Men who received 177Lu-PSMA-617 plus best standard of care had a 38% reduction in risk of death (median OS benefit of 4 months) and a 60% reduction in the risk of radiographic disease progression or death (median rPFS benefit of 5 months) compared to best standard of care alone. Mary-Ellen Taplin, Professor of Medicine and a GU Medical Oncologist at Dana-Farber Cancer Institute, joins Alicia Morga...
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- In a plenary presentation at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, Michael Morris, MD, presented awaited results of the Phase III VISION trial. The study is evaluating the efficacy and safety of 177Lu-PSMA-617, a targeted radioligand therapy in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) compared to best standard o...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen highlight a systematic review and meta-analysis examining the effectiveness and toxicities of lutetium-177-labeled prostate-specific membrane antigen-targeted radioligand therapy in metastatic castration-resistant prostate cancer, an article published in European Urology. Drs. Wallis and Klaassen detail the analysis, objective,...
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- Bennett Chin discusses Lutetium-177 PSMA, an investigational class of targeted, radionuclide agents. The focus of this treatment is on Prostate-Specific Membrane Antigen (PSMA), a molecule overexpressed on higher-grade prostate cancer cells. Lutetium-177 is a radioactive beta emitter that binds to PSMA, delivering highly targeted radiation therapy to prostate cancer cells. This emitter also has mi...
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- Recorded Date: September 8, 2020 The coronavirus disease 2019 (COVID-19) (SARS-CoV-2) pandemic necessitated rapid changes in medical practice. Many of these changes may add value to care, creating opportunities going forward. In this journal club, Zachary Klaassen, MD, MSc, and Christorpher Wallis, MD, PhD, discuss the impacts of the COVID-19 pandemic on genitourinary cancer care, and how we can r...
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