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Penile & Urethral Cancers

Human papillomavirus infection affects the immune microenvironment and antigen presentation in penile cancer.

Penile squamous cell carcinoma (PSCC) is a largely neglected condition, predominantly affecting underdeveloped regions, and is associated with risk factors such as low socioeconomic status, phimosis, and human papillomavirus (HPV) infection.

Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) in Penile Squamous Cell Carcinoma-No Evidence for a Role in Carcinogenesis.

Penile squamous cell carcinoma (pSCC) is a rare malignancy with a global incidence ranging from 0.1 to 0.7 per 100,000 males. Prognosis is generally favorable for localized tumors, but metastatic pSCC remains challenging, with low survival rates.

Impact of sarcopenia and fat distribution on outcomes in penile cancer.

Sarcopenia, defined as age-associated loss of skeletal muscle function and muscle mass, is a negative prognostic marker for survival in several tumor entities. However, data evaluating the impact of sarcopenia and fat distribution on penile cancer are rarely described.

The impact of diagnosis and treatment of penile cancer on intimacy: a qualitative assessment.

Penile cancer is a rare malignancy (0.5-0.93/100,000 in Western countries) with significant psychosocial and sexual repercussions. This qualitative study explored the impact of penile cancer diagnosis and treatment on intimacy.

Global Burden of Penile Cancer: A Review of Health Disparities for a Rare Disease - Beyond the Abstract

Penile cancer, primarily squamous cell carcinoma (SCC), presents a rare but aggressive malignancy, with an incidence of more than 2000 new cases and an estimated 470 deaths in the United States in 2023.1 Prior literature suggests that social determinants of health including environmental exposures, lifestyle, obesity, education, and less access to care are associated with an increased risk of cancer in general.2 This review explores the intersectionality of race, ethnicity, and socioeconomic status on penile cancer incidence and outcomes on a global scale.3

Molecular Characterization of Metastatic Penile Squamous Cell Carcinoma in Developing Countries and Its Impact on Clinical Outcomes: LACOG 2018 Translational Study - Beyond the Abstract

Penile squamous cell carcinoma (PSCC) is a rare disease corresponding to 0.2% neoplasm globally. However, in developing countries, the incidence rate may be up to five times higher than the rest of the world. In this way, some low-income regions in Brazil have the highest incidence of penile cancer in the world.

Serum cyfra21-1 is a new prognostic biomarker of penile squamous cell carcinoma.

Our study tried to evaluate the prognostic utility of preoperative serum cyfra21-1 in patients with penile squamous cell carcinoma (PSCC).

This retrospective study analyzed data from 94 patients who underwent either partial or radical penectomy accompanied by bilateral inguinal or pelvic lymphadenectomy at our institution from 2010 to 2018.

Programmed death-ligand expression and lymph node involvement in penile squamous cell carcinoma.

Our objective was to investigate the association between programmed death-ligand (PD-L1) immunoexpression measured as a combined positive score and clinical outcomes in penile SqCC.

We retrospectively reviewed all penile SqCC cases diagnosed in our institution between 2018 and 2023.

Indocyanine green and methylene blue dye guided sentinel lymph node biopsy in patients with penile cancer (PeCa): results of 50 inguinal basins assessed at a single institution in India.

The primary aim of this study was to validate the reliability, sensitivity and safety profile of novel combination of ICG- methylene blue dye as an SN tracer for PeCa.

This is a validation and non-randomised prospective observational study involving 25 patients (50 inguinal basins) who underwent SLNB where in ICG and methylene blue were used for localisation.

Follow Up Care After Penile Sparing Surgery for Penile Cancer: Current Perspectives.

Penile cancer (PeCa) is a rare urologic tumor worldwide. In 2024, 2100 new cases and 500 deaths are estimated in the United States. Radical surgery via total penectomy has historically been the cornerstone of treatment, since it provides excellent long-term oncological control.

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