Infections

European Association of Urology Guidelines on Urological Infections: Summary of the 2024 Guidelines.

Urological infections significantly impact the wellbeing and quality of life of individuals owing to their widespread occurrence and diverse clinical manifestations. The objective of the guidelines panel was to provide evidence-based guidance on the diagnosis, treatment, and prevention of urinary tract infections (UTIs) and male accessory-gland infections, while addressing crucial public health aspects related to infection control and antimicrobial stewardship.

Urinalysis Is Predictive for Absence of Urinary Tract Infection in Men with and Without Catheters - Beyond the Abstract

The goal of the study was to determine predictive accuracy of a negative urinalysis for negative urine culture and the absence of urinary tract infection in men both with and without indwelling urinary catheters. Similar to our findings in women (PMID 36898589), when urinalysis was negative (LE, WBC, nitrite) in men, only 5% of urine cultures grew uropathogenic bacteria, and only 1% of negative urinalyses were associated with urinary tract infection.

Urinalysis is predictive for absence of urinary tract infection in men with and without catheters.

To determine accuracy of negative urinalysis (UA) for predicting negative urine culture and the absence of urinary tract infection (UTI), and optimal urine culture growth cutoff for UTI diagnosis in men with and without urinary catheters.

Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group.

Background: Urinary tract infection (UTI) represents one of the most common infectious diseases and a major cause of antibiotic prescription in children. To prevent recurrent infections and long-term complications, low-dose continuous antibiotic prophylaxis (CAP) has been used.

Management of Urinary Tract Infection Symptoms in Older Women: A Survey of Practitioners

Importance: Urinary tract infection (UTI) is the most common bacterial infection for which empiric antibiotics are prescribed despite limited progression to urosepsis. More than half of antibiotics prescribed to older adults for a suspected UTI are considered unnecessary.

Objective: The aim of the study was to assess knowledge, attitudes, and practices regarding management of older women (>65 years) with symptoms attributed to UTIs among family and internal medicine providers.

Study design: This cross-sectional study surveyed 330 primary care providers in November 2021 regarding management of UTI symptoms. The primary outcome was the proportion of primary care providers who felt safe waiting for urine culture results before prescribing antibiotics in older women.

Results: The response rate was 43.0% (n = 142) with the majority of primary care providers practicing medicine more than 15 years (56.3%). For the primary outcome, 26.1% (n = 37) of primary care providers felt safe waiting for a urine culture result before prescribing antibiotics, while 62.0% (n = 88) felt delaying antibiotics depended on multiple factors, and 9.2% (n = 13) felt it was never safe to delay antibiotics. Primary care providers that either never felt it was safe to delay antibiotics or felt that "it depends" on a variety of factors, attributed their antibiotics administration to concern for progression to sepsis (n = 50, 49.5%) or progression of symptoms (n = 28, 27.7%). A higher proportion of primary care providers practicing more than 15 years felt safe delaying antibiotics compared with primary care providers with less experience (33.8% vs 18.3%, P = 0.04), and 70.3% of those who felt safe delaying antibiotics had more than 15 years of experience.

Conclusion: Primary care providers with more clinical experience have more comfort delaying antibiotics in older women with UTI symptoms.

Ashley Murillo, Selma Su, Halina Zyczynski, Megan Bradley

From the Division of Urogynecology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA.

Source: Murillo A, Su S, Zyczynski H, et al. Management of Urinary Tract Infection Symptoms in Older Women: A Survey of Practitioners. Urogynecology (Phila). 2024 Apr 1;30(4):452-456. doi: 10.1097/SPV.0000000000001416.

The REPAIR study: oral antibiotics to prevent infection and wound dehiscence after obstetric perineal tear-a double-blinded placebo controlled randomized trial.

Approximately 85% of women experience an obstetric tear at delivery and up to 25% subsequently experience wound dehiscence and/or infection. Previous publications suggest that intravenous antibiotics administrated during delivery reduces this risk.

Resident-, prescriber-, and facility-level factors associated with antibiotic use in long-term care facilities: a systematic review of quantitative studies.

Antimicrobial stewardship programmes are needed in long-term care facilities (LTCFs) to tackle antimicrobial resistance. We aimed to identify factors associated with antibiotic use in LTCFs. Such information would be useful to guide antimicrobial stewardship programmes.

The rationale for bladder washouts in children with neurogenic bladder.

Children with a neurogenic bladder are at risk of developing recurrent urinary tract infections and long-term kidney failure. Due to an altered lower urinary tract, children may be overtreated for simple bacteriuria or undertreated for a potentially severe urinary tract infection.

Robotic simple cystectomy as a last resort for antibiotic-recalcitrant recurrent urinary tract infections in women.

To report a series of women with antibiotic-recalcitrant recurrent urinary tract infections (rUTI) managed with robotic simple cystectomy and ileal conduit urinary diversion.

Following Institutional Review Board approval, all female patients who underwent robotic cystectomy for rUTI between 2011-2021 were identified from a prospectively-maintained internal database at a tertiary care center.

Recurrent Urinary Tract Infection Genetic Risk: A Systematic Review and Gene Network Analysis - Beyond the Abstract

Recurrent urinary tract infections (UTIs) encompass a multifaceted interaction of genetic elements, microbiome composition, and environmental factors (Figure 1). Previous studies showed specific genetic variations linked to the susceptibility of recurrent UTIs, including alterations in the HLA-B gene region.¹ Our current study, entitled “Recurrent urinary tract infection genetic risk: a systematic review and gene network analysis,” aimed to investigate genetic factors related to recurrent UTIs and compile the findings of previous research efforts that have reported on gene expression differences between patients with recurrent UTIs and healthy individuals.²

Page 1 of 106

Infections

Login