AUA 2014 - Bladder Cancer

#AUA14 - State-of-the-Art Lecture: Clinical implications of The Cancer Genome Atlas Project on muscle-invasive bladder cancer - Session Highlights

ORLANDO, FL USA (UroToday.com) - Dr. Seth Lerner from Baylor College of Medicine presented his group’s findings from The Cancer Genome Atlas (TCGA) project.

#AUA14 - Performance of primary radical cystectomy and risk of pathologic upstaging in patients with Stage I high grade urothelial carcinoma of the bladder: A National Cancer Database analysis - Session Highlights

ORLANDO, FL USA (UroToday.com) - The American Urological Association (AUA) guidelines recommend repeat TUR in patients with T1 tumors given the 30% risk of muscle invasive disease detection on re-staging.

#AUA14 - State-of-the-Art Lecture: Development of bladder cancer biomarkers - Session Highlights

ORLANDO, FL USA (UroToday.com) - Dr. Dan Theodorescu from the University of Colorado gave a “call to arms” for urologists to be aware of and develop biomarkers for bladder cancer.

#AUA14 - Poster: Performance of early radical cystectomy and risk of pathologic upstaging in patients with stage I high grade urothelial carcinoma of the bladder: A National Cancer Database analysis

ORLANDO, FL USA (UroToday.com) - Presented by Jeffrey J. Tomaszewski, Elizabeth Handorf, Charles W. Concodora, Reza Mehrazin, Alexander Kutikov, Rosalia Viterbo, David Y.T. Chen, Richard E. Greenberg, Robert G Uzzo, and Marc C. Smaldone at the American Urological Association (AUA) Annual Meeting - May 16 - 21, 2014 - Orlando, Florida USA

#AUA14 - Do circulating tumor cells help in decision-making regarding adjuvant chemotherapy in patients with urothelial carcinoma of the bladder treated with radical cystectomy? - Session Highlights

ORLANDO, FL USA (UroToday.com) - Dr. Armin Soave presented some very interesting data regarding the presence of circulating tumor cells (CTCs) in patients undergoing radical cystectomy (RC) for bladder cancer. The premise of the study is that presence of CTCs is a harbinger of poorer oncologic outcomes and might be an indication for chemotherapy after radical cystectomy (RC).

#AUA14 - Differential gene expression in responsive versus recurrent non-muscle invasive high-grade urothelial carcinomas after induction BCG - Session Highlights

ORLANDO, FL USA (UroToday.com) - Although BCG remains the intravesical therapy of choice, after TURBT, for high-grade non-muscle invasive bladder carcinomas (NMIBC), a recurrence and progression rate of up to 40% occurs after induction treatment. BCG failure likely can be attributed, at least partially, to inherent tumoral characteristics.

#AUA14 - The oxidative stress response of urothelial carcinoma cells to BCG exposure - Session Highlights

ORLANDO, FL USA (UroToday.com) - Cellular oxidative stress (COS), post BCG treatment, plays a central role in mediating direct effect of BCG on urothelial carcinoma (UC) cells.

#AUA14 - Predicting response to bacillus Calmette-Guerin (BCG) - Session Highlights

ORLANDO, FL USA (UroToday.com) - Dr. Ashish M. Kamat presented data his group has been accumulating in an effort to predict response to BCG in patients with non-muscle invasive bladder cancer (NMIBC).

#AUA14 - Neutrophil-to-lymphocyte ratio (NLR): Prognostic indicator for overall survival (OS) in patients undergoing radical cystectomy (RC) - Session Highlights

ORLANDO, FL USA (UroToday.com) - Inflammatory markers are known to predict outcomes in patients with hepatic, gastric, pancreatic, and kidney cancers. As such, authors sought to confirm initial data regarding the prognostic relevance of preoperative NLR for OS in patients undergoing RC for urothelial carcinoma of bladder.

#AUA14 - Is extended pharmacological venous thromboembolism prophylaxis uniformly safe following radical cystectomy? - Session Highlights

ORLANDO, FL USA (UroToday.com) - As the urologic community works to embrace wide-spread and regular use of perioperative chemical venous thromboembolism (VTE) prophylaxis for inpatients, emerging data reveal that a large proportion of symptomatic VTE events after abdominal and pelvic cancer surgery occur following hospital discharge.

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