Protease inhibitors are a source of nephrolithiasis in HIV + patients, and these stones are described as not detected by CT. While urinary stones are commonly associated with certain protease inhibitors, stones composed of ritonavir are rare. We present the case of a 58-year-old female on ritonavir-boosted atazanavir who presented to our clinic complaining of gross hematuria and flank pain secondary to a ureteral stone. Surgical removal revealed the stone to be composed of 100% ritonavir with no usual urinary stone components. This is the first report of an HIV medicine stone being detectable by CT scan described as 100% ritonavir.
Urology case reports. 2021 Jun 28*** epublish ***
Folawiyo Laditi, Amir Ishaq Khan, Eric M Ghiraldi, Tashzna Jones, Ankur Choksi, Dinesh Singh
Department of Urology, Yale School of Medicine, 789 Howard Avenue, New Haven, CT, 06519, USA.