UroAlert - GU Oncology Weekly

October 24, 2024

Videos

Peer-to-Peer Clinical Conversations

Humanized Mice Reveal Role of Immune System in Prostate Cancer Therapy Efficacy - Steven Kregel

Steven Kregel

Andrea Miyahira hosts Steven Kregel to discuss a published paper on humanized mouse models for metastatic prostate cancer.

Decipher® in mHSPC: Guiding Risk Assessment and Treatment Intensification - Gerhardt Attard

Gerhardt Attard

Nicholas James and Gerhardt Attard discuss findings from the STAMPEDE trial, focusing on molecular profiling of prostate cancer tumors.

Beyond the Abstracts

Cost-Utility Analysis of Navigate, a Treatment Decision Aid for Men with Prostate Cancer and Their Partners, in Comparison to Usual Care - Beyond the Abstract

Histopathological, Molecular and Clinical Profiling of Lymphoepithelioma-Like Carcinoma of the Bladder (LELC-B) - Beyond the Abstract

Conference Coverage

ESMO 2024: Empowering Bladder Cancer Care Integrating Patient Preferences and Voices

ESMO 2024: Histology Subtypes (variants) of Bladder Cancer

ESMO 2024: Clinical Prognostic Factors Within the High-Volume Subgroup of Metastatic Hormone Sensitive Prostate Cancer in ENZAMET (ANZUP 1304)

ESMO 2024: Hematologic Impact of [177Lu]Lu-PSMA-617 Versus ARPI Change in Patients with Metastatic Castration-Resistant Prostate Cancer in PSMAfore

ESMO 2024: First Preliminary Results of Artificial Intelligence Generated Treatment Recommendations for Urothelial Cancer Based on Multidisciplinary Cancer Conferences from the KITTU Project

ESMO 2024: Similar Genetic Profile in Early and Late Stage Urothelial Tract Cancer Suggests That Early Genomic Testing Bears the Potential of Timely Personalized Treatment in Clinical Trials

Physician-Scientist Review Articles

ESMO 2024 Quick Take Insights: Prostate Cancer

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

VI-RADS-Based Algorithm for Bladder Cancer Management Randomized Retrospective Study.

Comparing direct medical care costs of patients with bladder cancer who received an ileal conduit vs. neobladder in the year following cystectomy.

Comparative effectiveness of robot-assisted radical cystectomy with intracorporeal urinary diversion vs open radical cystectomy for bladder cancer.

Muscle-Invasive Bladder Cancer in Non-Curative Patients: A Study on Survival and Palliative Care Needs.

En Bloc Versus Conventional Transurethral Resection of Bladder Tumors: A Systematic Review and Meta-analysis of Oncological, Histopathological, and Surgical Outcomes.

Neoadjuvant chemotherapy before radical cystectomy in patients with organ-confined and non-organ-confined urothelial carcinoma.

Multiple Clinical Complete Responses Demonstrated Following Single Low Dose Administration of Bel-sar in Patients with Non-Muscle-Invasive Bladder Cancer (NMIBC) in Ongoing Phase 1 Trial

Cost-effectiveness Analysis in the New Era of Treatment Strategies in Metastatic Urothelial Carcinoma Based on Checkmate-901 and EV302/Keynote-A39.

The evolving role of multidisciplinary teams in optimizing Non-Muscle Invasive bladder cancer Care.

Undetectable pre-radical cystectomy circulating tumour DNA status predicts improved oncological outcomes.

National audit of patient reported experience of radical cystectomy for bladder cancer pathways.

Exposures and Bladder Cancer Risk Among Military Veterans: A Systematic Review and Meta-analysis - Beyond the Abstract

Comparative Effectiveness of Bacillus Calmette-Guérin and Sequential Intravesical Gemcitabine and Docetaxel for Treatment-naïve Intermediate-risk Non-muscle-invasive Bladder Cancer - Beyond the Abstract

Penile & Urethral Cancers

The impact of diagnosis and treatment of penile cancer on intimacy: a qualitative assessment.

Global Burden of Penile Cancer: A Review of Health Disparities for a Rare Disease - Beyond the Abstract

Renal Cancer

GLYAT suppresses liver cancer and clear cell renal cell carcinoma progression by downregulating ROCK1 expression.

Resveratrol enhances sensitivity of renal cell carcinoma to tivozanib: An in-vitro study.

Guiding treatment decisions in renal cell carcinoma: the role of biomarkers and clinical factors.

Cytoreductive Nephrectomy Following Immunotherapy for Metastatic Renal Cell Carcinoma and IVC Tumor Thrombus Arising from a Horseshoe Kidney.

A case report of robot-assisted radical nephrectomy and inferior vena cava thrombectomy in a patient with renal cell carcinoma after pembrolizumab and axitinib combination therapy.

Prognosis and progression of phagocytic regulatory factor-related gene combinations in clear cell renal cell carcinoma (ccRCC).

Surgical Experience and Functional Outcomes after Laparoscopic and Robot-Assisted Partial Nephrectomy: Results from a Multi-Institutional Collaboration.

TFE3-Rearranged Tumors of the Kidney: An Emerging Conundrum.

Efficacy of immune checkpoint inhibitor combination therapy prior to nephrectomy in advanced renal cell carcinoma: A retrospective pilot study.

Efficacy and Safety of Pembrolizumab plus Axitinib combination for Metastatic Renal Cell Carcinoma in a Real-World Scenario: Data From the Prospective ProPAXI Study.

Differences in Mutations Across Tumour Sizes in Clear-Cell Renal Cell Carcinoma - Beyond the Abstract

Prostate Cancer

Optimizing prostate cancer detection in transition zone: an analysis of apparent diffusion coefficient values in prostate magnetic resonance imaging evaluation with Prostate Imaging Reporting and Data System (PI-RADS) assessment.

Should Military Veterans Be Classified as High Risk for Prostate Cancer Screening? A Systematic Review and Meta-analysis.

Racial disparities in prostate cancer in the UK and the USA: similarities, differences and steps forwards.

Clinical Factors Associated with Suspicious 18F-DCFPyL PSMA PET Activity in Patients Initially Managed with Radical Prostatectomy including PSA <0.5 ng/mL.

The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2.

Ferroptosis-related gene signature predicts prognosis and immune microenvironment in prostate cancer.

Effect of Prednisone Dosing on Mineralocorticoid-Related Side Effects With Abiraterone in Prostate Cancer.

Prostate cancer screening and management in patients candidate for endoscopic enucleation of the prostate: an international survey.

Protein kinase D1 mitigation against etoposide induced DNA damage in prostate cancer is associated with increased α-Catenin.

Acute pancreatitis and biliary obstruction from metastatic lymph node compression during [177Lu] Lu-PSMA-617 therapy: a case report.

Prostate-specific Membrane Antigen (PSMA) Spatial Biomarker: Standardized Positron Emission Tomography Disease Maps Provide Accurate Prediction of Overall Survival in Prostate Cancer.

Sequential [177Lu]Lu-PSMA-617 and Docetaxel Versus Docetaxel in Patients with Metastatic Hormone-Sensitive Prostate Cancer (UpFrontPSMA): A Multicentre, Open-Label, Randomised, Phase 2 Study - Beyond the Abstract

Optimizing risk stratification for intermediate-risk prostate cancer - the prognostic value of baseline health-related quality of life.

Multivariable models of outcomes with [177Lu]Lu-PSMA-617: analysis of the phase 3 VISION trial.

Comparison of Transatlantic Recommendations for Prostate Gland Evaluation with MRI after Focal Therapy (TARGET) and Prostate Imaging after Focal Ablation (PI-FAB) for Detecting Recurrent Prostate Cancer at Prostate MRI.

Comparative efficacy and safety of talazoparib plus enzalutamide and other first-line treatments for metastatic castration-resistant prostate cancer.

Castration Levels of Testosterone Results in Atrophy of Androgen-Sensitive Perineal Muscles: A Potential Biomarker for Male Hypogonadism.

Novel Radiopharmaceuticals and Future of Theranostics in Genitourinary Cancers

Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Diet Quality, Dietary Inflammatory Potential, and Risk of Prostate Cancer Grade Reclassification.

Urologic oncology case volume among early career urologists: An analysis of certification data from the American board of urology between 2003 and 2019.

All that glitters is not gold: high uptake on PSMA PET in non-prostate cancers does not mean that treatment with [177Lu]Lu-PSMA-radioligand will be successful.

Gastrin Releasing Peptide Receptors-targeted PET Diagnostics and Radionuclide Therapy for Prostate Cancer Management - Beyond the Abstract

A Targeted Methylation-Based Multicancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer While Minimizing Overdiagnosis of Indolent Disease - Beyond the Abstract

Relugolix Plus Enzalutamide For Metastatic Hormone-Sensitive Prostate Cancer: A Case Report.

Extraperitoneal Robot-Assisted Radical Prostatectomy with the Hugo™ RAS System: Initial Experience at a High-Volume Robotic Centre.

Simultaneous Autophagy and Androgen Receptor Inhibition in a Prostate Cancer Xenograft Model.

Drug Interactions between Androgen Receptor Axis-Targeted Therapies and Antithrombotic Therapies in Prostate Cancer: Delphi Consensus.

Prostate-specific Membrane Antigen Positron Emission Tomography Before Reaching the Phoenix Criteria for Biochemical Recurrence of Prostate Cancer After Radiotherapy: Earlier Detection of Recurrences.

Sleep and health improvement programme (SHIP) for patients with prostate cancer and caregivers.

Revisiting HER2 in Prostate Cancer from an Inclusive Perspective: From Biomarkers to Omics.

Targeted Prostate Health Checks, a novel system to identify men with prostate cancer-A pilot study.

Molecular Correlates of Prostate Cancer Visibility on Multiparametric Magnetic Resonance Imaging: A Systematic Review.

Aerobic Physical Activity and Depression Among Patients With Cancer A Systematic Review and Meta-Analysis

How Can Participant Experience of Quality-of-Life Research Be Improved in Cancer Research: Views of the Patient and Public Involvement Representatives from the STAMPEDE2 Prostate Cancer Trial - Beyond the Abstract

Prostate Cancer Early Detection in the European Union and UK - Beyond the Abstract

Local Salvage Therapies in Patients with Radio-Recurrent Prostate Cancer Following External Beam Radiotherapy: A Systematic Review and Meta-Analysis - Beyond the Abstract

Upper Tract Tumors

The biologic landscape and therapeutic implications of upper tract urothelial cancer.

Outcomes of laparoscopic, robotic and open nephroureterectomy with bladder cuff excision in patients with T3T4 upper urinary tract urothelial carcinoma: a multi-center retrospective study.

Survival impact of variant histology in patients with upper tract urothelial carcinoma after radical nephroureterectomy.

Survival Outcomes Across Surgical Approaches in Octogenarians with UTUC - Expert Commentary

Testicular Cancer

The Utility of Immuno-Nutritional Scores in Patients with Testicular Germ Cell Tumors.

Comparison of clinical characteristics of testicular tumor between children and adult population: a retrospective analysis.

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