UroAlert - GU Oncology Weekly

December 04, 2024

Videos

Peer-to-Peer Clinical Conversations

Olaparib Effective in BRCA2-Altered Biochemical Recurrence Post-Prostatectomy in Phase 2 Study - Catherine Handy Marshall

Catherine Marshall

Cathy Marshall discusses a non-randomized clinical trial evaluating olaparib without androgen deprivation therapy for high-risk biochemically recurrent prostate cancer following prostatectomy.

JCOG1019 Trial Examines Watchful Waiting vs BCG for High-Grade T1 Bladder Cancer - Hiroshi Kitamura

Hiroshi Kitamura

Zachary Klaassen interviews Hiroshi Kitamura about the JCOG1019 study, examining watchful waiting versus BCG therapy in high-grade T1 bladder cancer patients with no residual tumor after second TUR.

Beyond the Abstracts

Voided Urine Cytology Is a Useful Tool Predicting Non-Muscle-Invasive Bladder Cancer Risk Before Surgery - Beyond the Abstract

Patient's Self-Reported Quality of Life as a Prognostic Factor in Metastatic Renal Cell Carcinoma Initially Treated with TKI: Nomogram Proposal - Beyond the Abstract

Conference Coverage

SUO 2024: New Approaches to NMIBC Surgery

SUO 2024: Emerging Treatments and New Targets for Metastatic Urothelial Cancer

SUO 2024: Keynote Lecture: Precision in Urothelial Carcinoma – FGFR

Physician-Scientist Review Articles

Survival Outcomes Across Surgical Approaches in Octogenarians with UTUC - Expert Commentary

Treatment Preferences and Tradeoffs Among Patients with Locally Advanced or Metastatic Urothelial Carcinoma - Expert Commentary

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

Assessing the influence of smoking on inflammatory markers in bacillus Calmette Guérin response among bladder cancer patients: a novel machine-learning approach.

Intraoperative Tranexamic Acid in Radical Cystectomy: Impact on Bleeding, Thromboembolism, and Survival Outcomes.

The efficacy of sequential intravesical gemcitabine and docetaxel versus BCG for the treatment of European association of urology very-high risk non-muscle invasive bladder cancer.

A Phase 2 Trial of Intravesical Gemcitabine and Docetaxel in the Treatment of Bacillus Calmette-Guérin‒Naïve Nonmuscle-Invasive Urothelial Carcinoma of the Bladder

The Management of Non-Muscle-Invasive Bladder Cancer in a Veteran Patient Population: Issues and Recommendations.

Use of Multiparametric and Biparametric Magnetic Resonance Imaging in Bladder Cancer Staging: Prospective Observational Study and Analysis of Radiologist Learning Curve.

Rationale of restaging transurethral resection of bladder tumor in patients with nonmuscle invasive bladder cancer in the current era.

Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial.

Cohort Profile: VZNKUL-NMIBC Quality Indicators Program: A Flemish Prospective Cohort to Evaluate the Quality Indicators in the Treatment of Non-Muscle-Invasive Bladder Cancer.

Bacillus Calmette-Guérin (BCG) Refractory Non-Muscle-Invasive Bladder Cancer (NMIBC): Current Guidance and Experience from Clinical Practice.

Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer.

Penile & Urethral Cancers

Body mass index and penile cancer incidence: results from a Norwegian cohort study of 829,081 men.

Penile cancer : a comprehensive review of diagnostics and treatment approaches.

Gene Expression Profiling of the Peritumoral Immune Cell Infiltrate of Penile Squamous Cell Carcinomas.

Identification of new tissue markers for the monitoring and standardization of penile cancer according to the degree of differentiation.

Renal Cancer

Validation of Prognostic Models for Renal Cell Carcinoma Recurrence, Cancer Specific Mortality and All-Cause Mortality.

Prospective Study of Patient, Nursing, and Oncology Provider Perspectives on Telemedicine Visits for Renal Cell Carcinoma Clinical Trials.

Renal cell carcinoma with inferior vena cava thrombus: Survival and prognostic factors in surgically treated patients.

Combining Transarterial Embolization and Percutaneous Cryoablation for Early-Stage Renal Cell Carcinoma: Embolization Materials and Impacts of Tumor Size.

Late Survival and Long-Term Follow-Up After Radical Resection of Advanced Renal Cell Carcinoma With Associated Venous Tumor Thrombus.

STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma.

Adverse events after nivolumab and ipilimumab combined immunotherapy in advanced renal cell carcinoma: a multicentre experience in Poland.

Comparison of outcomes between single-port and multi-port robotic radical nephrectomy.

Calcium Channel Blocker Versus Renin-Angiotensin System Inhibitor in Risk of Kidney Cancer Among Patients With Hypertension: A Propensity Score-Matched Cohort Study.

Primary resistance to nivolumab plus ipilimumab therapy affects second-line treatment outcomes in patients with metastatic renal cell carcinoma.

Prostate Cancer

Whole-gland or Subtotal High-intensity Focused Ultrasound Versus Radical Prostatectomy: The Prospective, Noninferiority, Nonrandomized HIFI Trial

Landmark HIFI Study Publication Demonstrates Positive Outcomes with Focal One® Robotic HIFU Versus Surgery in the Management of Prostate Cancer

First 2 Participants Dosed with Cu-64 SAR-bisPSMA in Co-PSMA Trial

Nectin-4 Positivity in Genitourinary Malignancies: A Systematic Review.

Prostate cancer in people with HIV.

Implementing evidence-based strategies for men with biochemically recurrent and advanced prostate cancer: Consensus recommendations from the US Prostate Cancer Conference 2024.

Evaluating the Prognostic Impact of Apparent Diffusion Coefficient in Definitive Radiotherapy for Gleason Score 7 Prostate Cancer Patients.

Surgical and oncological outcomes of salvage radical prostatectomy after focal therapies: a matched-pair analysis.

Intratumoral heterogeneity drives acquired therapy resistance in a patient with metastatic prostate cancer.

Safety of PSMA radioligand therapy in mCRPC patients with preexisting moderate to severe thrombocytopenia.

Adipose Tissues Have Been Overlooked as Players in Prostate Cancer Progression.

Preoperative Briganti Nomogram Score and Risk of Prostate Cancer Progression After Robotic Surgery Beyond EAU Risk Categories.

Hugo™ Versus daVinci™ Robot-Assisted Radical Prostatectomy: 1-Year Propensity Score-Matched Comparison of Functional and Oncological Outcomes.

Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies.

Active surveillance follow-up for prostate cancer: from guidelines to real-world clinical practice.

Systematic literature review and meta-analysis of health state utility values in metastatic castration-resistant prostate cancer.

Cross-shaped windows transformer with self-supervised pretraining for clinically significant prostate cancer detection in bi-parametric MRI.

Germline sequence variation in cancer genes in Rwandan breast and prostate cancer cases.

Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors.

ASCL1 regulates and cooperates with FOXA2 to drive terminal neuroendocrine phenotype in prostate cancer.

Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment.

Gene-based burden tests of rare germline variants identify six cancer susceptibility genes.

Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function.

Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition.

Extracapsular extension risk assessment using an artificial intelligence prostate cancer mapping algorithm.

Targeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer.

Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming.

Nutritional Supplement with Fermented Soy in Patients Under Active Surveillance for Low-Risk or Intermediate-Risk Prostate Cancer: Results from the PRAEMUNE Trial.

Phenotypic evaluation of deep learning models for classifying germline variant pathogenicity.

Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression.

Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer.

Upper Tract Tumors

Squamous cell carcinoma of the upper urinary tract: clinical characteristics, treatment patterns, and survival outcomes in the National Cancer Database.

Kidney-Sparing Management of UTUC in Solitary Kidney Patients: A Retrospective Analysis and Narrative Review.

The role of intravesical chemotherapy following nephroureterectomy in upper tract urothelial carcinoma: A systematic review and meta-analysis.

Testicular Cancer

Long-term Relapse and Survival in Clinical Stage I Testicular Teratoma.

The effect of chemotherapy regimens in male germ cell tumors on the development of primary hypogonadism.

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