We evaluated the effectiveness of injecting autologous adipose-derived regenerative cells (ADRCs) into plaque in men with chronic Peyronie's disease (PD).
This pilot safety study recruited 22 Danish men with chronic PD from an outpatient clinic. Patients received one bolus of ADRCs injected into plaque, with follow-ups at 1, 3, 6, and 12 mo. The primary endpoint was a reduction in penile curvature. Secondary endpoints were serious adverse events in relation to treatment, and patient-reported results for improvements, distress, and unhappiness related to PD.
There was no significant difference in curvature after treatment. However, the participants reported subjective improvements, less distress, and a decrease in unhappiness. No severe adverse events were observed during 12-mo follow-up.
Injections of ADRCs into PD plaque appear to be safe but had no significant measurable effect on penile curvature. Half of the participants reported a subjective improvement.
We studied the safety and effectiveness of injections of patient-derived regenerative cells for chronic Peyronie's disease. While the curvature of the penis did not significantly improve, the treatment was safe and some men reported a decrease in their distress and an improvement in penile shape.
European urology open science. 2024 Dec 31*** epublish ***
Majken H Wiborg, Rasmus Krøijer, Birgitte S Laursen, Wahida Chakari, Charlotte Harken Jensen, Jens Ahm Sørensen, Lars Lund
Department of Urology, Hospital South West Jutland, Esbjerg, Denmark., Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Clinical Nursing Research Centre, Aalborg University Hospital, Aalborg, Denmark., Research Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark., Clinical Institute, University of Southern Denmark, Odense, Denmark.