AUA 2017: Predicting Renal Cell Carcinoma Progression after Surgery
Over 3500 patients were identified and analyzed, with clear cell carcinoma representing 77% of the cohort. Based on a median follow-up of 9.9 years, constitutional symptoms, increasing grade, presence of coagulative necrosis, sarcomatoid differentiation, larger tumor size, perinephric or renal sinus fat invasion, tumor thrombus level, worse than T3 stage, and nodal status were statistically significant predictors of PFS. In addition to the aforementioned features, age at surgery and Eastern Cooperative Oncology Group performance status were also statistically significant predictors of CSS.
Some 17% of the cohort was papillary RCC with a median follow-up of 10.3 years. Grade, perinephric or renal sinus fat invasion, and tumor thrombus were statistically significant predictors of PFS and CSS. Lastly, 6% of the cohort was chromophobe with a median follow-up of 9.1 years. PFS was predicted by the presence of sarcomatoid differentiation, perinephric or renal sinus fat invasion, and nodal involvement. None of the factors were able to foresee CSS for chromophobe RCC.
These models are useful in counseling patients in survival outcomes for the various RCC subtypes and should be validated with future prospective studies.
Presented By: William Parker, MD
Co-Authors: William Parker, Md; Christine Lohse, John Cheville, MD; Harras Zaid, MD; Stephen Boorjian, MD; Igor Frank, MD; R Houston Thompson, MD; Bradley Leibovich, MD
Institution: Mayo Clinic, Rochester, MN
Written By: David B. Cahn, DO, MBS, Fox Chase Cancer Center, Philadelphia, PA
Twitter: @dbcahn
at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA