In his study, he gathered 38 rats and divided them into 4 groups: Sham group that underwent 60 minutes of laparotomy, Sham Quercetin group that received 50 mg/kg of quercetin, Ischemia group that underwent 60 minutes of left renal ischemia, and a Ischemia Quercetin group that also received 50 mg/kg of quercetin. The drug was administered intraperitoneally 3 days before surgery then 3 days after surgery. After four weeks, he then evaluated the renal volume, cortex non-cortex areas ratios, glomerular volume densities, mean values of glomerular volumes, and the number of glomeruli per kidney.
Those rats that received quercetin had higher cortex-non-cortex area ratios, higher glomerular volume densities, and a higher number of glomeruli per kidney when compared to those rats that did not receive quercetin. However, only in the glomerular volume densities was there any difference that was statistically significant.
In conclusion, warm renal ischemia promotes considerable damage to the kidney and prophylactic administration of quercetin was shown to have protective effects on the renal cortex in this study. This may suggest the possibility for use of this drug as a prophylaxis against kidney damage prior to partial nephrectomies. The next steps would be to begin clinical trials with this substance.
Presented by: Francisco Sampaio, MD, Full Professor and Head, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
Co-Authors: Gabriela Gonçalves, Rio de Janeiro, Rio de Janeiro, Brazil, Bianca Gregório – State University of Rio de Janeiro, Rio De Janeiro, Rio de Janeiro, Brazil, Marco Pereira-Sampaio – Urogenital Research Unit, Rio De Janeiro, Rio de Janeiro, Brazil,Diogo De Souza – Urogenital Research Unit, Rio De Janeiro, Rio de Janeiro, Brazil
Written by: John Sung, Department of Urology, University of California-Irvine, medical writer for UroToday.com at the 36th World Congress of Endourology (WCE) and SWL - September 20-23, 2018 Paris, France