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WCE 2017: Experimental Study for a New Medical Adhesion-Prevention Agent after Laparoscopic Nephrectomy

Vancouver, Canada (UroToday.com) Yasuyuki Naitoh, associate professor from the Kyoto Prefectural University of Medicine Kyoto, presented a new adhesion-prevention agent. Adhesion of body tissues occurring after laparoscopic surgery not only causes adhesive intestinal obstruction but may cause a number of side effects such as chronic abdominal pain and infertility. Existing biodegradable and bioabsorbable adhesion-prevention agents used in clinical practice are sheet-like products, which require fixation onto tissues, and they are difficult to handle during laparoscopic surgery. Dr. Naitoh presents a novel medical adhesion-prevention agent in powder form. It acts as an adhesive during the fixation process and after fixation it acts as an adhesion-prevention agent.

They performed laparoscopic nephrectomy on 16 rabbits for evaluation of adhesion-prevention effect. Rabbits were separated into 4 groups, in which the intact kidney was sprayed with saline (control) or the agent, and post-nephrectomy rabbits were sprayed with saline or the agent. They created a grading system to evaluate both macroscopically and histologically the level of adhesion in the abdominal cavity, and the frontal surface and nephrectomized region of the kidney relative to the intestine/mesentery.

Dr Naitoh’s group found adhesions in the saline post-nephrectomy group that required blunt dissection and identified infiltration of inflammatory cells histologically. However, no adhesions were observed between the nephrectomized region and the intestine/mesentery when the nephrectomized region was covered with new adhesion-prevention agent. These results confirm that their novel adhesion-prevention powder agent could be beneficial for laparoscopic surgery. 

Presented by: Yasuyuki Naitoh

Authors: Yasuyuki Naitoh, Jun Ajiki, Atsuko Fujihara, Motohiro Kanazawa, Soh Ushijima, Fumiya Hongo, Koji Okihara, Hyon Suong-Hyu, Osamu Ukimura 
Affiliation: Department of Urology, Kyoto Prefectural University of Medicine Kyoto, Kyoto, Japan

Written by: Egor Parkhomenko, Department of Urology, University of California-Irvine at 35th World Congress of Endourology– September 12-16, 2017, Vancouver, Canada.