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- Daniel Joyce discusses the financial impact of advanced prostate cancer treatments on patients. He presents research showing significant out-of-pocket costs for oral cancer therapies, particularly for commercially insured patients. Dr. Joyce highlights disparities in costs based on factors like age, race, and income. He emphasizes the importance of addressing financial toxicity in patient care, no...
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- Amy Reed discusses a study on diversity, equity, and inclusion in urolithiasis clinical trials over the past two decades. The research analyzes 180 trials, examining patient enrollment by race, ethnicity, and sex. Using a representation quotient, the study finds that white patients are adequately represented, Black patients are overrepresented, while Hispanic and mixed-race patients are underrepre...
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- Mark Ball and Jessica Hsueh discuss a study on using GPT-4 for data extraction from renal surgery operative notes. The research compares GPT-4's performance to human-curated data across five variables: laterality, surgery type, approach, estimated blood loss, and ischemia time. Results show high accuracy for categorical variables but lower accuracy for continuous variables and heterogeneously writ...
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- Piet Ost discusses the STORM trial, a randomized study comparing stereotactic body radiotherapy (SBRT) with elective nodal radiotherapy (ENRT) in oligometastatic prostate cancer patients. The trial, involving 80% PSMA-PET scanned patients, includes six months of androgen deprivation therapy in both arms. Results show significant benefits for ENRT in biochemical recurrence-free survival and locoreg...
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- Rashid Sayyid and Zach Klaassen discuss a meta-analysis published in JAMA Oncology examining cardiovascular events associated with androgen receptor signaling inhibitors (ARSIs) in advanced prostate cancer. The study analyzes 24 randomized controlled trials across various prostate cancer stages, involving 22,166 patients. Results show a significant increase in both all-grade and grade 3+ cardiovas...
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- Brian Flynn discusses the emerging field of functional urology. Dr. Flynn defines functional urology as a comprehensive approach to non-cancer, non-stone, adult urological issues, focusing on restoring patients' functionality. He positions it as a bridge between reconstructive and traditional urology, emphasizing the need for expertise in both surgical techniques and physiological understanding. D...
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- In this follow-up discussion, Badar Mian and E David Crawford delve deeper into the implications of clinical trials comparing transperineal (TP) and transrectal (TR) prostate biopsies. They address key issues such as antibiotic use, patient comfort, and sampling accuracy. Dr. Mian notes that many European centers still use antibiotics for TP biopsies, contrary to claims of antibiotic avoidance. Th...
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- Badar Mian discusses randomized clinical trials comparing transperineal (TP) and transrectal (TR) prostate biopsy approaches. Despite previous beliefs favoring TP biopsies for lower infection rates and better cancer detection, three major trials (ProBE-PC, PREVENT, and PERFECT) show no significant differences in sepsis rates or cancer detection between the two methods. The studies reveal similar m...
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- Valeska Halstead discusses a survey study examining pediatric urologists' perceptions of US News and World Report rankings. The study, with a 51% response rate from Society for Pediatric Urology members, reveals significant skepticism about the ranking system's validity. Notably, 86% of respondents support withdrawing from the rankings, with even 75% of those in top-10 institutions agreeing. Most...
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- Giulia Marvaso discusses the RADIOSA trial, a phase II randomized study comparing SBRT alone versus SBRT with short-course hormonal therapy for oligorecurrent prostate cancer. The trial includes 102 patients with up to three metastatic lesions, randomized into two arms. Results show improved biochemical and clinical progression-free survival in the combination arm. Dr. Marvaso highlights that pati...
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