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Machine Learning Predicts Financial Toxicity in Stage IIA Non-Seminoma Treatments
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Peter Sullivan, DO
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| Peter Sullivan discusses a study on financial toxicity in testicular cancer treatment. The study employs large language machine learning models and Markov modeling to predict financial toxicity patterns in stage IIA non-seminoma patients, comparing retroperitoneal lymph node dissection (RPLND) versus chemotherapy treatment approaches.
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Highlights from the 2024 South Central Section of the AUA Annual Meeting |
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| Can We Predict Locally Advanced Disease Features with PSMA PET? Correlation of Molecular Imaging TNM with Pathological TNM in Radical Prostatectomy Specimen
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| Carlos A. Gonzalez-Martinez, MD
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| Carlos Gonzalez-Martinez presents a study examining the correlation between PSMA PET and pathological TNM staging in prostate cancer. The findings show a strong correlation (0.831, p<0.001) between PSMA PET features and pathological evidence of locally advanced disease, with PSMA PET achieving a positive predictive value of 100% for adverse features in prostatectomy specimens. This suggests PSMA PET may be valuable in guiding treatment decisions, such as integrating multimodal therapy or selecting radiotherapy over surgery.
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| Can the PSMA PET SUVmax Predict High-Risk Pathology and High-Risk Disease? A Single Center Prospective Disease
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| Jorge Alcacio-Mendoza, MD
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| Jorge Alcacio-Mendoza presents a study showing that PSMA PET SUVmax can effectively predict high-risk pathology and advanced disease in prostate cancer. A cutoff of SUVmax 9 was highly predictive of ISUP grade ≥4 pathology, with a positive predictive value of 81%, and a strong association with locally advanced disease. These findings support using SUVmax as a guide for treatment planning, potentially identifying patients who may benefit from more aggressive, multimodal approaches.
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| Elucidating the Response Rates to Additional BCG: Implications for Clinical Trial Design |
| Amanda Myers, MD |
| Amanda Myers presents a study on response rates to additional BCG in patients with NMIBC, differentiating between "BCG-exposed" and "BCG-unresponsive" groups. Results show high complete response rates: 79% for BCG-exposed and 75% for BCG-unresponsive patients, with prolonged disease-free survival. These findings provide essential reference data for powering clinical trials and underscore the need for BCG as a control arm in trials for BCG-exposed NMIBC patients. |
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| Multiparametric MRI in the Evaluation of Small Renal Masses |
| Jeffrey Cadeddu, MD |
| Jeffrey Cadeddu presents multiparametric MRI (mpMRI) with the clear cell Likelihood Score (ccLS) as a non-invasive, cost-effective alternative to biopsy for evaluating small renal masses. The ccLS enables accurate identification of clear cell RCC, aids in decision-making for cT1a tumors, and supports active surveillance of indolent masses, minimizing unnecessary biopsies. |
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| Should Veterans be Classified as High-Risk for Prostate Cancer Screening: A Review of the Current Literature
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| Gal Saffati, MD
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| Gal Saffati presents a systematic review assessing whether veterans should be classified as high risk for prostate cancer screening. Findings showed a higher prostate cancer incidence among veterans, with exposures like Agent Orange and aromatic hydrocarbons (e.g., benzene) significantly increasing risk. Dr. Saffati suggests that veterans might benefit from enhanced screening protocols, although more research is needed to solidify these exposure-risk associations.
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| Pelvic Exenteration and Urologic Complications: A 90-Day Audit of the Practice at a Single Tertiary Level Medical Center |
| Anish Patel, DO |
| Anish Patel presented a 90-day review of urologic complications following pelvic exenteration at a tertiary medical center. Among 39 patients, major complications (Clavien-Dindo 3+) occurred in 38%, with a 43.6% readmission rate. Key findings highlighted increased complication risks with diabetes and higher BMI, and suggested that using sigmoid or colonic conduits over ileal conduits could lead to improved outcomes in some cases. |
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| Does the Use of Continuous Bladder Irrigation After TURBT Increase the Risk of Complications? |
| Clare M. Wieland |
| Clare Weiland presents findings on the potential risks associated with continuous bladder irrigation (CBI) after transurethral resection of bladder tumor (TURBT). The study examined data from 92 TURBT cases at CHI Hospitals in Omaha, Nebraska, from 2018-2022, comparing outcomes between patients who received CBI either in the operating room or postoperatively and those who did not. |
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| Financial Toxicity in Testicular Cancer Treatment, Validated Questionnaire Correlated Software Cost Modeling |
| Peter Sullivan, DO |
| Peter Sullivan presented research on financial toxicity in testicular cancer treatment, utilizing a validated questionnaire and artificial intelligence software to assess the economic impact of various treatment strategies, including retroperitoneal lymph node dissection (RPLND) and chemotherapy. The study found that while RPLND initially incurs higher costs, it generally leads to lower long-term financial burdens and toxicities compared to chemotherapy, which results in escalating expenses due to ongoing treatment and long-term side effects. |
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