To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: "high symptom burden," "high sexual bother," and "low symptom burden." Men with "high symptom burden" were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with "high symptom burden" also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.
Journal of behavioral medicine. 2022 Feb 02 [Epub ahead of print]
Blanca Noriega Esquives, Tae K Lee, Patricia I Moreno, Rina S Fox, Betina Yanez, Gregory E Miller, Ryne Estabrook, Mark J Begale, Sarah C Flury, Kent Perry, Shilajit D Kundu, Frank J Penedo
Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 1006, Miami, FL, 33136, USA. ., Department of Convergence for Social Innovation, Department of Child Psychology and Education, Sungkyunkwan University, Seoul, South Korea., Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 1006, Miami, FL, 33136, USA., College of Nursing, University of Arizona, Tucson, USA., Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, USA., Institute for Policy Research and Department of Psychology, Northwestern University, Evanston, USA., Health Outcomes and Behavior Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA., Vibrent Health, Fairfax, USA., Department of Urology, Vanderbilt University School of Medicine, Nashville, USA., Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, USA., Department of Psychology, University of Miami, Coral Gables, USA.