To evaluate the impact of chronic stone recurrence on an individual's quality of life using the validated Wisconsin Stone Quality of Life (WISQOL) questionnaire. We collected cross-sectional data on patients with kidney stones from 14 institutions in North America. A stone event was defined as renal colic, stone-related procedure or emergency department visit. The regression analyses using general linear models and pairwise comparison determined the impact of the number of stone events on quality of life. The median number of stone events among the 2205 patients who completed the questionnaire was 3 (IQR 1-6). The mean total score was 107.4 ± 28.7 (max 140 points). The number of lifetime stone events was an independent predictor of lower quality of life (p < 0.001), specifically, score declined significantly beyond five events. Compared with patients who experienced a single stone event, there was a 0.4, 2.5, and 6.9 point decline in the adjusted mean WISQOL score after 2-5, 6-10, or > 10 events, respectively. The cumulative number of lifetime stone events was associated with a lower quality of life when more than five stone events were occurred. These findings underscore the importance of efforts to determine the underlying metabolic etiology of urolithiasis in the recurrent stone former, and the institution of a regimen to place their stone disease in remission.
Urolithiasis. 2021 Jan 06 [Epub ahead of print]
Shlomi Tapiero, Luke Limfuco, Seth K Bechis, Roger L Sur, Kristina L Penniston, Stephen Y Nakada, Jodi A Antonelli, Necole M Streeper, Sri Sivalingam, Davis P Viprakasit, Timothy D Averch, Zhamshid Okhunov, Roshan M Patel, Thomas Chi, Vernon M Pais, Ben H Chew, Vincent G Bird, Sero Andonian, Naeem Bhojani, Noah E Canvasser, Jaime Landman
Department of Urology, University of California Irvine, 333 City Blvd W, Suite 2100, Orange, CA, 92868, USA. ., Department of Urology, University of California Irvine, 333 City Blvd W, Suite 2100, Orange, CA, 92868, USA., Department of Urology, University of California San Diego, San Diego, CA, USA., Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Division of Urology, Pennsylvania State University College of Medicine, Hershey, PA, USA., Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA., Department of Urology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Department of Urology, Palmetto Health USC Medical Group, Columbia, SC, USA., Department of Urology, University of California San Francisco, San Francisco, CA, USA., Urology Section, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA., Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada., Department of Urology, University of Florida College of Medicine, Gainesville, FL, USA., Division of Urology, McGill University Health Center, Montreal, QC, Canada., Division of Urology, University of Montreal, Montreal, QC, Canada., Department of Urology, University of California Davis, Sacramento, CA, USA.