Urology and Nephrology Research Center (UNRC), Shahid Labbafinejad Medical Center, Shahid Beheshti University, M.C. (SBMU), Urology, No.44, Boostan 9th St, Pasdaran, Tehran, Iran, Islamic Republic of, 1666679951.
To demonstrate the safety and efficacy of percutaneous nephrolithotomy (PCNL) for management of large renal stones between single-functioning kidney and double-kidney patients.
Thirty single-functioning kidneys and thirty double-kidney patients with a mean age of 38.5 (±15.6) years in single group and 42.1 (±14.3) years in double group (range 11-72 years) underwent PCNL for renal stones larger than 2 cm. The effect of PCNL on global and regional cortical activity was measured using quantitative single-photon emission CT (SPECT) measurement of 99mTc-dimercaptosuccinic acid (DMSA) scan uptake by the kidneys before and 6 months after PCNL. Variables assessed were stone bulk, size, location, the number of punctures and anatomic factors. Average hemoglobin and serum creatinine changes, mean operative time, transfusion rate, hospital stay and different complications were also assessed.
Mean stone size, mean hospital stay, success rate and complications were statistically similar in both groups. Mean serum creatinine changes (pre-op & post-op) were not statistically significant between two groups (p-value =0.12). Mean hemoglobin drop (pre-op & post-op) in both groups were significant, and there was valuable difference between them (p-value =0.01).There was significant difference in the uptake by the treated kidneys before versus after PCNL between both groups statistically (p-value =0.019), so that DMSA renal uptake was obviously higher 6 months after PCNL in double-kidney group compared to its uptake in single-functioning kidney group.
99mTc-DMSA renal scan confirms that renal function was preserved or even often improved after percutaneous stone removal, and procedure had no detrimental effects on renal function in both groups. There was no statistically significant difference between these groups in terms of morbidity and stone clearance.
Written by:
Basiri A, Shabaninia S, Mir A, Soltani MH. Are you the author?
Reference: J Endourol. 2011 Nov 3. Epub ahead of print.
doi: 10.1089/end.2011.0083
PubMed Abstract
PMID: 22050500
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