We aimed to review the current evidence on surgical and functional outcomes of Transperineal Laser Ablation for LUTS due to BPH. A comprehensive review of the English-language literature was performed using the MEDLINE and Web of Science databases until 1 August 2022, aiming to select studies evaluating TPLA for the treatment of LUTS due to BPH. Additional records were found from Google Scholar. Data were extracted and summarized in Tables. An appropriate form was used for qualitative data synthesis. Seven studies were included in the review, with all being single arm, non-comparative studies. In all studies, functional outcomes were evaluated with uroflowmetry parameters and validated questionnaires, showing a promising effectiveness at short- and mid-term follow-up. There is a lack of standardized pathways for preoperative assessment of patients suitable for TPLA, and even the technique itself has been reported with a few nuances. A good safety profile has been reported by all the authors. Although promising results have been reported by different groups, selection criteria for TPLA and few technical nuances regarding the procedure were found to be heterogeneous across the published series that should be standardized in the future. Further research is needed to confirm these findings.
Journal of clinical medicine. 2023 Jan 19*** epublish ***
Francesco Sessa, Paolo Polverino, Giampaolo Siena, Claudio Bisegna, Mattia Lo Re, Pietro Spatafora, Alessio Pecoraro, Anna Rivetti, Luisa Moscardi, Marco Saladino, Andrea Cocci, Mauro Gacci, Vincenzo Li Marzi, Marco Carini, Andrea Minervini, Riccardo Campi, Sergio Serni
Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, 50100 Florence, Italy., Unit of Oncologic Minimally Invasive Urology and Andrology, University of Florence, Careggi Hospital, 50100 Florence, Italy., Department of Experimental and Clinical Medicine, University of Florence, 50100 Florence, Italy.