To determine the factors that may be associated with a 2-month high baseline level of Total Prostatic Specific Antigen (PSA) after endoscopic enucleation of the prostate with Holmium Laser (HoLEP).
Retrospective study of a prospectively collected database of adult males undergoing HoLEP at a single tertiary institution from September 2015 to February 2021.
Pre-operative epidemiological, clinical characteristics and post-operative factors were analyzed and a multivariate analysis was performed to determine factors independently related to PSA decline.
A total of 175 men aged 49-92 years with a prostate size ranging from 25 to 450 cc underwent HoLEP, and after excluding data from patients due to loss of follow-up or incomplete data, 126 patients were included in the final analysis. The patients were divided into group A (n = 84), which included patients with postoperative PSA nadir lower than 1 ng/ml, and group B(n = 42), with postoperative PSA levels greater than 1 ng/ml. In the univariate analysis there was a correlation between the variation of the PSA value and the percentage of resected tissue (p = 0.028), for each 1 g of resected prostate there was a reduction of 0.104 ng/mL, furthermore there was a difference between the means of age of group A (71.56 years) and group B (68.17 years) (p = 0.042). In the multivariate analysis, the use of statins and lower postoperative PSA levels (p = 0.024; HR = 3.71) were correlated.
Our results indicate that PSA after HoLEP is correlated with patient's age, the presence of incidental prostate cancer, and the use of statins.
World journal of urology. 2023 Jun 16 [Epub ahead of print]
Caio Vinícius Suartz, Natália Doratioto Serrano Faria Braz, Gabriel Carvalho Dos Anjos, Sabrina Thalita Dos Reis, William Carlos Nahas, Alberto Azoubel Antunes
Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil. ., Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/37326653
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