Objective: To evaluate the learning curve of the "Double Grooves-Double Rings" (DGDR) technique of transurethral Thulium laser enucleation of the prostate (ThuLEP) for benign prostatic hyperplasia (BPH) by a single surgeon. From June 2021 to July 2022, 84 patients mean age (69.0±8.0) years,preoperative prostate volume (90.9±40.3)ml with BPH underwent ThuLEP in the Department of Urology, Peking University First Hospital.Performed by a single surgeon who had no experience of transurethral resection of prostate (TURP) and any laser surgeries. The case scatter plots with the best fitting line were drawn to analyze the learning curve. According to the date of the surgeries, the patients were equally divided into three learning stages (28 patients for each group). The T-PSA,prostate volume,operative time,enucleation time, enucleation efficiency,catheter indwelling time, hemoglobin drop and perioperative complications (including re-TURP, blood transfusion, stress incontinence≥3 months and urethral stricture) were compared among the groups. The learning curve was divided into three stages, and the cutting point was shown on the 14th case. Except the prostate volume [stage1 (75.7±30.7) ml, stage2 (93.40±39.6)ml, stage3 (103.5±46.2) ml, P<0.05], there was no significant difference of the baseline data between three groups (P>0.05). Compared with those of stage 1(100.6±24.7) min,(0.55±0.22) g/min, a statistically significant improvement was observed in both of the operative time and the enucleation efficiency among stage 2[(84.5±36.6) min, (0.87±0.33) g/min and stage 3 (71.2±26.3) min, (1.27±0.45) g/min, P<0.05]. The learning curve of the DGDR technique for ThuLEP can be divided into three stages. A ThuLEP beginner can preliminarily master this technique after completing 14 cases.
观察单一术者应用“双沟双环法”经尿道铥激光前列腺剜除术（ThuLEP）治疗良性前列腺增生（BPH）的学习曲线，总结可用于推广该术式的教学方法。回顾性分析2021年6月至2022年7月于北京大学第一医院泌尿外科单一无经尿道前列腺电切术（TURP）或激光前列腺手术经验的泌尿外科医师使用“双沟双环法”ThuLEP治疗的84例BPH患者的临床资料，患者年龄（69.0±8.0）岁，术前前列腺体积（90.9±40.3）ml，依照接受手术先后顺序，绘制具有最佳拟合线的病例散点图以分析学习曲线，根据学习曲线划分不同学习阶段；比较每一阶段的前列腺剜除效率、导尿管留置时间、手术前后血红蛋白下降值、围手术期并发症情况（2次TURP止血、输血、术后3个月压力性尿失禁、尿道狭窄）等。结果显示以前列腺剜除效率达到平台期为标志，“双沟双环法”ThuLEP手术的学习曲线分为初学期、掌握期和熟练期三个阶段，第三个阶段的前列腺体积（103.5±46.2）ml明显大于前两个阶段［第一阶段（75.7±30.7）ml、第二阶段（93.4±39.6）ml，P<0.05］，其余数据差异均无统计学意义（均P>0.05），但后两个阶段在手术时间［掌握期（84.5±36.6）min、熟练期（71.2±26.3）min］和剜除效率［掌握期（0.87±0.33）g/min、熟练期（1.27±0.45）g/min］上显著优于第一阶段［（100.6±24.7）min、（0.55±0.22）g/min，P<0.05）］。进一步分析发现，学习曲线在第一阶段的14例手术后达到平台期，将第一阶段进行组间分析，术者完成后14例的剜除效率（0.86±0.42）g/min显著优于完成前14例的剜除效率（0.55±0.23）g/min（P<0.05）。“双沟双环法”ThuLEP手术的学习曲线可分为初学期、掌握期和熟练期；无TURP或激光前列腺剜除手术经验的泌尿外科医师经过该培训方式可在开展14例后初步掌握ThuLEP手术技术。.
Zhonghua yi xue za zhi. 2023 May 30 [Epub]
C Zuo, K L Yang, Z C Li, Y M Gu, Y Z Diao, X B Meng, Y S Meng, K Zhang
Department of Urology,Peking University First Hospital,Beijing 100034,China Department of Urology, Beijing Miyun District Hospital,Beijing 101500,China., Department of Urology,Peking University First Hospital,Beijing 100034,China., Department of Urology, Beijing Miyun District Hospital,Beijing 101500,China.