To describe clinical outcomes among patients with benign prostatic hyperplasia (BPH) 24 months following prostatic artery embolization (PAE).
This was an international, multicenter, prospective trial of males with BPH with lower urinary tract symptoms (LUTS) or acute urinary retention (AUR) treated with PAE. The primary outcome was the 12 month change in the International Prostate Symptom Score (IPSS) for patients referred for bothersome LUTS, or urinary catheter independence for patients treated for AUR. Secondary outcome measures included changes in IPSS at 3 and 24 months, changes in quality of life (QoL), changes in the Sexual Health Inventory for Men (SHIM) questionnaire, technical success rate, and adverse events (AEs). Data were summarized using descriptive statistics.
Four hundred seventy-eight consecutive patients underwent PAE (bothersome LUTS: N = 405; AUR: N = 73), mean age was 70 years. For patients treated for bothersome LUTS, mean total IPSS at baseline was 21.8 and decreased to 9.3, 10.6, and 11.2 at 3, 12, and 24 months following PAE, respectively (all p < 0.001); QoL at baseline was 4.7 and decreased to 2.0, 2.1, and 2.3 at 3, 12, and 24 months, respectively (all p < 0.001). The mean SHIM score at baseline and 12 months following PAE was 13.8 and 13.9, respectively. Of the 73 patients treated for AUR, 48 (65.8%) had their indwelling catheter removed within 3 months of PAE and remained catheter free at 24 months. Fifty-five patients (11.5%) experienced ≥ 1 AE and 10 (2.1%) experienced a serious AE.
PAE is a safe and effective treatment for symptomatic BPH and LUTS. Level of Evidence Level 3 Trial registration ClinicalTrials.gov NCT03527589.
Cardiovascular and interventional radiology. 2024 Sep 04 [Epub ahead of print]
Marc R Sapoval, Shivank Bhatia, Carole Déan, Antonio Rampoldi, Francisco César Carnevale, Clare Bent, Charles R Tapping, Simone Bongiovanni, Jeremy Taylor, Jayson S Brower, Michael Rush, Justin P McWilliams, Mark W Little, PROstate Study Investigators
Department of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015, Paris, France. ., Department of Interventional Radiology, Miller School of Medicine, University of Miami, Miami, FL, USA., Department of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015, Paris, France., Department of Interventional Radiology, Ospedale Niguarda Ca' Granda, Milan, Italy., Department of Radiology, Instituto de Radiologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Department of Interventional Radiology, Royal Bournemouth and Christchurch Hospital, Bournemouth, UK., Department of Radiology, The Churchill Hospital, Oxford, UK., Department of Radiology, Azienda Ospedaliera S. Croce E Carle, Cuneo, Italy., Department of Interventional Radiology, Frimley Park Hospital, Surrey, UK., Department of Radiology, Providence Sacred Heart, Spokane, WA, USA., Holy Cross South Florida Medical Imaging, Fort Lauderdale, FL, USA., Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., University Department of Radiology, Royal Berkshire Hospital, Reading, UK.