University of Texas, MD Anderson Cancer Center, Houston, TX.
Henry Ford Hospital, Detroit, MI; Xcenda, Palm Harbor, FL; GlaxoSmithKline, Research Triangle Park, NC, USA.
Study Type - Prevalence (prospective cohort with good follow-up) Level of Evidence 1b.
To compare prostate cancer, prostate-related surgery and acute urinary retention rates, as well as associated healthcare resource use over 11 years in African American and Caucasian men with benign prostatic hyperplasia (BPH).
The BPH-related medical and surgical charges and events were determined for 398 African American men and 1656 Caucasian men followed for a mean of 10.2 years within a health maintenance organization. Racial differences in clinical outcomes were evaluated using time-to-event analysis, stratifying results by baseline prostate-specific antigen (PSA) values.
Risk of a prostate cancer diagnosis was 2.2 times greater in African American than Caucasian men (95% CI 1.48-3.35, P < 0.001) in analyses adjusting for serum PSA level. Although African Americans were more likely to receive medical therapy for symptoms of BPH than Caucasians (43.5% vs 37.2%, respectively; P= 0.029), there were no clinically meaningful differences with respect to subsequent acute urinary retention or BPH-related surgery between them, or BPH-related medical charges (US $407 vs US $405 per month).
As evidenced by this analysis of 'real-world' clinical practice, African Americans with BPH have a much greater risk of developing prostate cancer than similar Caucasian men highlighting the need for education and early detection in this population.
Written by:
Pettaway CA, Lamerato LE, Eaddy MT, Edwards JK, Hogue SL, Crane MM. Are you the author?
Reference: BJU Int. 2011 Mar 4. Epub ahead of print.
doi: 10.1111/j.1464-410X.2010.09991.x
PubMed Abstract
PMID: 21371244
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