OBJECTIVE: To compare holmium laser enucleation (HoLEP) versus open prostatectomy (OP) for large volume benign prostatic hyperplasia.
METHODS: The randomized controlled trials (RCTs) pertaining to HoLEP and OP for management of large volume benign prostatic hyperplasia were retrieved from Medline and Embase. Meta-analysis was performed using Review Manager 5.0 software.
RESULTS: Three RCTs were included in the analysis. No significant differences were found in IPSS or Qmax between HoLEP and OP (P>0.05). Compared with OP, HoLEP was associated with significantly less blood loss, a shorter catheterization time and a shorter hospital stay, but a longer operating time. HoLEP and OP were similar in terms of urethral stricture, stress incontinence, transfusion requirement and the rate of reintervention.
CONCLUSION: HoLEP and OP have similar therapeutic effects in the management of large volume benign prostatic hyperplasia. Although with a longer operating time and less resected tissue, HoLEP causes less blood loss and requires a shorter catheterization time and a shorter hospital stay. HoLEP has a comparable safety to OP in terms of the adverse events.
Written by:
Chen H, Tang P, Ou R, Deng X, Xie K. Are you the author?
Graduate School of Southern Medical University, Guangzhou, China.
Reference: Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jun;32(6):882-5.
doi: 10.3969/j.issn.1673-4254.2012.06.028
PubMed Abstract
PMID: 22699076
Article in Chinese.
