Lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) commonly affect older men.
These bothersome symptoms can lead to a decreased quality of life. Currently, two classes of drugs - α-adrenergic blockers and 5α-reductase inhibitors - are prescribed to treat LUTS secondary to BPH. Due to their different mechanisms of action, these medications work in a synergistic manner. Trials of combination therapy have been conducted to assess its effect compared with monotherapy. Current data support combination therapy in men with moderately enlarged prostates and moderate to severe symptoms.
Written by:
Chughtai B, Elterman DS, Lee R, Te AE, Kaplan SA. Are you the author?
James Buchanan Brady Department of Urology, Weill Cornell Medical College of Cornell University, New York, USA.
Reference: Ther Adv Urol. 2012 Oct;4(5):267-72.
doi: 10.1177/1756287212457115
PubMed Abstract
PMID: 23024707
