OBJECTIVE: To evaluate the efficacy and safety of fesoterodine extended-release (ER) plus tamsulosin in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).
PATIENTS AND METHODS: Men aged ≥50 years, with LUTS, prostate volume ≤ 60 ml and International Prostate Symptom Score (IPSS) ≥13 were enrolled in this study. 173 consecutive patients were treated initially with tamsulosin (0.4 mg) for 1 week. At the second visit, 47 patients out of the sample of 173 who were still experiencing inconvenient LUTS were randomized into two groups. The first group received a therapy with tamsulosin and fesoterodine combination (group 1, n = 24) while the second continued the therapy with the single administration of tamsulosin (group 2, n = 23) for an additional 4-week period.
RESULTS: There was no statistically significant difference in age, prostate volume, Qmax, and postvoid residual urine between the two groups. A statistical significance appeared in the combination group regarding the storage and the total IPSS values among the second and third visits (10.5 ± 1.4 to 8.5 ± 1.3 and 16.1 ± 1.8 to 13.7 ± 1.5 respectively).
CONCLUSION: Regarding bothersome LUTS and storage symptoms, fesoterodine ER and tamsulosin combination was significantly more effective than the single administration of tamsulosin.
Written by:
Konstantinidis C, Samarinas M, Andreadakis S, Xanthis S, Skriapas K. Are you the author?
Department of Urology, National Institute of Rehabilitation, Athens, Greece.
Reference: Urol Int. 2013;90(2):156-60.
doi: 10.1159/000345050
PubMed Abstract
PMID: 23221480
