Epidemological studies have confirmed that benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) are correlated, independent of age or comorbidities as diabetes.
Although researchers have not yet established a direct causal relationship between the two problems, several pathophysiological factors may serve to explain it, which include the alteration in nitric oxide bioavailability, increased autonomic activity, a1-adrenergic receptor hyperactivity, imbalance of RhoA/Rho-kinase, and metabolic syndrome X. Men seeking care for BPH should always be screened for sexual function and complaints of ED. PDE5 inhibitors show promise as a future treatment for lower urinary tract symptoms secondary to BPH. Further investigation is required for future therapies and possible preventative strategies.
Written by:
Fan Y. Are you the author?
Department of Andrology, Mianyang Central Hospital, Mianyang, Sichuan 821000, China.
Reference: Zhonghua Nan Ke Xue. 2013 Jun;19(6):572-5.
PubMed Abstract
PMID: 23862240
Article in Chinese.
