This is the first study to investigate the influence of depression, anxiety and somatization on the treatment response for lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH).
The LUTS/BPH patients were evaluated with the Korean versions of the International Prostate Symptom Score (IPSS), the Patient Health Questionnaire-9 (PHQ-9), the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the PHQ-15. The primary endpoint was a responder rate defined by the total score of IPSS (≤ 7) at the end of treatment. The LUTS/BPH severity was significantly higher in patients with depression (whole symptoms P = 0.024; storage sub-symptom P = 0.021) or somatization (P = 0.024) than in those without, while the quality of life (QOL) was significantly higher in patients with anxiety (P = 0.038) than in those without. Anxious patients showed significantly higher proportion of non-response (odds ratio [OR], 3.294, P = 0.022) than those without, while somatic patients had a trend toward having more non-responders (OR, 2.552, P = 0.067). Our exploratory results suggest that depression, anxiety and somatization may have some influences on the clinical manifestation of LUTS/BPH. Further, anxious patients had a lower response to treatment in patients with LUTS/BPH. Despite of limitations, the present study demonstrates that clinicians may need careful evaluation of psychiatric symptoms for proper management of patients with LUTS/BPH.
Written by:
Yang YJ, Koh JS, Ko HJ, Cho KJ, Kim JC, Lee SJ, Pae CU. Are you the author?
Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea; Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea; Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, Korea; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Reference: J Korean Med Sci. 2014 Aug;29(8):1145-51.
doi: 10.3346/jkms.2014.29.8.1145
PubMed Abstract
PMID: 25120327
