OBJECTIVE: Central obesity can be associated with the development of benign prostatic enlargement (BPE) and with the worsening of lower urinary tract symptoms (LUTS).
The aim of our study was to evaluate the impact of components of Metabolic Syndrome (MetS) on urinary outcomes after surgical therapy for severe LUTS due to BPE.
MATERIALS AND METHODS: A multicenter prospective study was conducted including 378 consecutive men surgically treated for large BPE with simple open prostatectomy (OP) or transurethral resection of the prostate (TURP), between January 2012 and October 2013. LUTS were measured by the International Prostate Symptom Score (IPSS), immediately before surgery and 6 to 12 months postoperatively. MetS was defined according the US National Cholesterol Education Program-Adult Treatment Panel III.
RESULTS: The improvement of total and storage IPSS postoperatively was related to diastolic blood pressure and waist circumference (WC). WC >102 cm was associated with a higher risk of an incomplete recovery of both total IPSS (OR: 0.343, p=0.001) and storage IPSS (OR: 0.208, p< 0.001), as compared to WC< 102cm. Main limitations are: 1) population selected for a tertiary center 2) Use exclusively of IPSS questionnaire 3) Not inclusion of further data.
CONCLUSIONS: Increased WC is associated with persistent postoperative urinary symptoms after surgical treatment of BPE. Obese men have a higher risk of persistent storage LUTS after TURP or OP.
Written by:
Gacci M, Sebastianelli A, Salvi M, De Nunzio C, Tubaro A, Vignozzi L, Corona G, McVary K, Kaplan S, Maggi M, Carini M, Serni S. Are you the author?
Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.
Reference: BJU Int. 2015 Jan 18. Epub ahead of print.
doi: 10.1111/bju.13038
PubMed Abstract
PMID: 25597623