OBJECTIVE: To determine the relationship between LUTS/BPH and 10-year risk of CVD assessed by the Framingham Cardiovascular Risk score in a cohort of patients without previous episodes of stroke and/or acute myocardial infarction.
PATIENTS AND METHODS: Between September 2010 to September 2014, 336 consecutive patients with BPH related LUTS were prospectively enrolled. The general 10-year cardiovascular disease Framingham risk score, expressed as a percent and assessing the risk of atherosclerotic cardiovascular disease (CVD) events was calculated for each patients. Respectively, individuals with low risk had 10% or less CVD risk at 10 years, with intermediate risk 10-20%, and with high risk 20% or more. Logistic regression analyses were carried out to identify variables for predicting Framingham risk score ≥ 10% and moderate-severe LUTS (IPSS≥ 8) adjusted for confounding factors.
RESULTS: As category of Framingham risk score increased, we observed higher IPSS (18.0 vs. 18.50 vs. 19.0; p< 0.05), high IPSS-voiding (6.0 vs. 9.0 vs. 9.5; p< 0.05) and worse sexual function. Prostate volume significantly increased in intermediate vs. low risk (54.5 vs. 44.1; p< 0.05). Multivariate logistic regression analysis showed that intermediate (OR: 8.65; p< 0.01) and high risk (OR: 1.79; p< 0.05) were independently associated with moderate-severe LUTS. At age adjusted logistic regression analysis, moderate-severe LUTS were independently associated with Framingham risk score ≥ 10 % (OR: 5.91; p< 0.05).
CONCLUSION: Our cross-sectional study in a cohort of patients with LUTS/BPH showed an increase of more than 5-fold of having a Framingham risk score ≥ 10 % in men with moderate-severe LUTS.
Written by:
Russo GI, Castelli T, Privitera S, Fragalà E, Favilla V, Reale G, Urzì D, La Vignera S, Condorelli R, Calogero AE, Cimino S, Morgia G. Are you the author?
Department of Urology, University of Catania, Italy.
Reference: BJU Int. 2015 Jan 20. Epub ahead of print.
doi: 10.1111/bju.13053
PubMed Abstract
PMID: 25601421