OBJECTIVE: To evaluate the clinical impact of peripheral zone thickness (PZT), based on presumed circle area ratio (PCAR) theory, on urinary symptoms in men with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) as a novel prostate parameter.
PATIENTS AND METHODS: Medical records were obtained from a prospective database of first-visit men with LUTS/BPH. Age, international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), maximum flow rate (Qmax), and post-void residual (PVR) were assessed. Total prostate volume (TPV), transition zone volume (TZV), and transition zone index (TZI), and PZT were measured from transrectal ultrasonography. Reliability analysis was also performed.
RESULTS: A total of 1009 patients were enrolled for the analysis. Mean PZT was 11.10 ± 2.50 mm, and patients were classified into 3 groups; PZT < 9.5 mm, 9.5 mm ≤ PZT < 13 mm, and PZT ≥ 13 mm. As PZT became smaller, all urinary symptom scores including IPSS, QoL, and OABSS significantly increased. Uroflowmetric parameters such as Qmax and PVR also showed significant differences. PZT showed a high intra-class correlation coefficient (0.896). Multivariate analysis revealed that PZT was independently associated with IPSS (p < 0.001), QoL (p = 0.003), OABSS (p = 0.001), and PVR (p = 0.001), but PZT influence on Qmax was only of borderline significance (p=0.055).
CONCLUSION: PZT is a novel, easy-to-measure prostate parameter that is significantly associated with urinary symptoms. Our findings suggested that clinical usefulness of PZT should be further validated for managing men with LUTS/BPH.
Written by:
Kwon JK, Han JH, Choi HC, Kang DH, Lee JY, Kim JH, Oh CK, Choi YD, Cho KS. Are you the author?
Department of Urology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Reference: BJU Int. 2015 Mar 23. Epub ahead of print.
doi: 10.1111/bju.13130
PubMed Abstract
PMID: 25807886