The Arthur Smith Institute for Urology, North Shore - Long Island Jewish Health System, New Hyde Park, NY 11010, USA.
Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction (ED). Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease (SCD) and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.
Written by:
Levey HR, Kutlu O, Bivalacqua TJ. Are you the author?
Reference: Asian J Androl. 2011 Nov 7. Epub ahead of print.
doi: 10.1038/aja.2011.114
PubMed Abstract
PMID: 22057380
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