BACKGROUND: Erectile Dysfunction (ED) is associated with increased risk of coronary artery disease (CAD).
OBJECTIVE: To evaluate the association between ED, determined by the Simplified International Index of Erectile Function (IIEF-5) and CAD.
METHODS: This was a cross-sectional cohort study that evaluated 263 hypertensive patients (55 [50-61] years). ED was assessed through the IIEF-5 and CAD by the history of previous myocardial revascularization and/or coronary angiography.
RESULTS: The IIEF-5 correlated with creatinine clearance [CrCl] (Rho = 0.23, p < 0.001) and age (Rho = -0.22, p < 0.001). Forty-two patients had CAD, and IIEF-5 was able to discriminate them (area under the ROC curve = 0.63, p = 0.006). Patients were divided into two groups: IIEF-5 < 20 (n = 140) and IIEF-5 > 20 (n = 123); those with lower IIEF-5 scores were older (57 [52-61] vs. 54 [45-60] years, p = 0.002), had higher prevalence of CAD (22% vs. 9%, p = 0.004), smoking (64% vs. 47%, p = 0.009) and use of calcium channel inhibitors (65% vs. 43.%, p = 0.001), as well as lower CrCl (67.3 [30.8 to 88.6] vs. 82.6 [65.9 - 98.2] ml/min, p < 0.001). The IIEF-5 < 21 was associated with increased risk of CAD in the logistic regression, both univariate (RR = 2.89 [95%CI: 1.39 - 6.05]), and after adjusting for age, diabetes, CrCl, smoking, mean arterial pressure and use of antihypertensive drugs (RR = 2.59 [95% CI: 1.01 - 6.61]).
CONCLUSION: The IIEF-5 is associated with the diagnosis of CAD and its use can add information to cardiovascular risk staging in hypertensive patients.
Written by:
Cordeiro AC, Mizzaci CC, Fernandes RM, Araujo-Junior AG, Cardoso PO, Dutra LV, Sousa AG, Amodeo C. Are you the author?
Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brasil.
Reference: Arq Bras Cardiol. 2012 Oct;99(4):924-930.
doi: 10.1590/S0066-782X2012005000081
PubMed Abstract
PMID: 22936031
Article in English, Portuguese.
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