OBJECTIVES: Caffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED) in population-based studies.
We investigated the association of caffeine intake and caffeinated beverages with ED, and whether these associations vary among comorbidities for ED.
MATERIAL AND METHOD: Data were analyzed for 3724 men (≥20 years old) who participated in the National Health and Nutrition Examination Survey (NHANES). ED was assessed by a single question during a self-paced, computer-assisted self-interview. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable logistic regression analyses using appropriate sampling weights were conducted.
RESULTS: We found that men in the 3rd (85-170 mg/day) and 4th (171-303 mg/day) quintiles of caffeine intake were less likely to report ED compared to men in the lowest 1st quintile (0-7 mg/day) [OR: 0.58; 95% CI, 0.37-0.89; and OR: 0.61; 95% CI, 0.38-0.97, respectively], but no evidence for a trend. Similarly, among overweight/obese and hypertensive men, there was an inverse association between higher quintiles of caffeine intake and ED compared to men in the lowest 1st quintile, P≤ 0.05 for each quintile. However, only among men without diabetes we found a similar inverse association (Ptrend = 0.01).
CONCLUSION: Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.
Written by:
Lopez DS, Wang R, Tsilidis KK, Zhu H, Daniel CR, Sinha A, Canfield S. Are you the author?
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas- Houston School of Public Health, Houston, TX, United States of America; Division of Urology, University of Texas- Houston Medical School, Houston, TX, United States of America; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology, University of Texas- MD Anderson Cancer Center, Houston, TX, United States of America; Division of Biostatistics, University of Texas- Houston School of Public Health, Houston, TX, United States of America.
Reference: PLoS One. 2015 Apr 28;10(4):e0123547.
doi: 10.1371/journal.pone.0123547
PubMed Abstract
PMID: 25919661