To investigate a possible relation between penile Doppler ultrasound examination (PDUE) parameters and efficacy of chronic therapy with tadalafil (TAD) combined with a protocol of aerobic physical activity (PA) in patients with late onset hypogonadism (LOH).
The study evaluated 30 patients consecutively enrolled with LOH and erectile dysfunction which present contraindication to hormonal replacement therapy for concomitant prostate disease. These patients were subjected to a combined protocol with phosphodiesterase V selective inhibitors (TAD 5 mg daily) and aerobic PA.
After three months, we observed significant improvements in erectile function [IIEF-5, median (IQR) = 13.0 (7.0-18.0) versus 6.0 (5.0-6.75); p < 0.01] and of the main metabolic [homeostatic model assessment index, median (IQR) = 2.5 (1.62-3.37) versus 3.0 (2.0-3.75); p < 0.01; body mass index, median (IQR) = 27.0 (24.0-28.75) versus 27.5 (24.0-29.5)] and vascular parameters [peak systolic velocity, median (IQR) = 29.5 (24.25-31.0) versus 28.0 (23.0-24.25); acceleration time, median (IQR) = 114 (105.25-134.0) versus 115.0 (106.5-134.0)], assessed by PDUE.
PA in association with phosphodiesterase V inhibitors could compensate the effects of hypogonadism on erectile function and facilitate the clinical response to these drugs even in the absence of adequate serum concentrations of total testosterone.
The aging male : the official journal of the International Society for the Study of the Aging Male. 2016 May 06 [Epub ahead of print]
Rosita A Condorelli, Aldo E Calogero, Maurizio Di Mauro, Laura M Mongioì, Giorgio I Russo, Giuseppe Morgia, Sandro La Vignera
a Department of Clinical and Experimental Medicine - CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes) , University of Catania , Catania , Italy ., a Department of Clinical and Experimental Medicine - CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes) , University of Catania , Catania , Italy ., b CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes), University of Catania , Catania , Italy , and., a Department of Clinical and Experimental Medicine - CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes) , University of Catania , Catania , Italy ., c Department of Urology , University of Catania , Catania , Italy., c Department of Urology , University of Catania , Catania , Italy., a Department of Clinical and Experimental Medicine - CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes) , University of Catania , Catania , Italy .