Coffee intake is suggested to have a positive role against chronic diseases. Yet, the role of coffee in urological diseases such as erectile dysfunction (ED) remains unclear. Thus, we investigated the association of coffee intake with incidence of ED. A prospective analysis of 21,403 men aged 40-75 years old was conducted using the Health Professionals Follow-Up Study. Total coffee, regular and decaffeinated coffee intakes were self-reported on food-frequency questionnaires. ED was assessed by means of questionnaires in 2000, 2004 and 2008. Multivariable adjusted Cox proportional hazards models were used to compute hazard ratios (HR) for incident ED (N = 7,298). No significant differences were identified for incident ED after comparing highest (≥ 4 cups/day) with lowest category (0 cups/day) of total- (HR = 1.00; 95% CI: 0.90 - 1.11) and regular- coffee intakes (HR = 1.00; 95% CI: 0.89 - 1.13). For decaffeinated coffee intake, after comparing the highest category with lowest category, we found a 37% increased risk of ED (HR = 1.37; 95% CI = 1.08-1.73) with a significant trend (Ptrend = 0.02). Stratified analyses showed an association among current smokers (Ptrend = 0.005).Overall, long-term coffee intake was not associated with risk of ED in a prospective cohort study.
American journal of epidemiology. 2017 Aug 23 [Epub ahead of print]
David S Lopez, Lydia Liu, Eric B Rimm, Konstantinos K Tsilidis, Marcia de Oliveira Otto, Run Wang, Steven Canfield, Edward Giovannucci