Department of Urology, University Vita-Salute San Raffaele, Milan.
Department of Obstetrics and Gynecology, University Vita-Salute San Raffaele, Milan, Italy.
This study was aimed at assessing presence and predictors of a trend towards more advanced paternal age at presentation in a cohort of 1283 Caucasian-European infertile couples with male factor infertility (MFI) over a short time frame. Multivariate linear regression analysis tested the association between predictors [namely, partners' age, length of infertility at first presentation, patients' comorbidities as scored with the Charlson Comorbidity Index (CCI) and educational status] and patient's age at presentation. Using anova, patient's age at presentation (F ratio: 2.43; p = 0.024) and patients' educational status (χ2 trend: 142.38; p < 0.001) significantly increased over time. In contrast, length of infertility at first presentation, CCI and partners' age did not significantly change over time (all p ≥ 0.05). Linear regression analyses showed that CCI, educational status and year of presentation were not correlated with patients' age at presentation (all p ≥ 0.05), whereas partners' age (β = 0.170; p < 0.001) and length of infertility (β = 0.123; p = 0.004) were independent predictors of delayed fatherhood. These results showed a significant shift towards advanced paternal age, but a non-significant increase of maternal age at first presentation among Caucasian-European infertile couples with MFI over a short time frame.
Written by:
Salonia A, Matloob R, Saccà A, Ferrari M, Gallina A, Castiglione F, Abdollah F, Raber M, Brigante C, Candiani M, Rigatti P, Montorsi F. Are you the author?
Reference: Int J Androl. 2011 Jun 22. Epub ahead of print.
doi: 10.1111/j.1365-2605.2011.01197.x
PubMed Abstract
PMID: 21696399
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