Antisperm antibodies (ASA) are one well-known cause of refractory infertility in both males and females.
In females, a sperm immobilization test, which detects sperm-immobilizing antibodies indirectly in the patient's serum, requires complement for the reaction and thus seems to be a more specific immunological reaction. In males, an immunobead test or a mixed antiglobulin reaction test, which detects ASA directly on the sperm surface, is a screening test because of the nonspecific reaction.
Written by:
Shibahara H, Koriyama J. Are you the author?
Department of Obstetrics & Gynecology, School of Medicine, Jichi Medical University, and Center for Reproductive Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan.
Reference: Methods Mol Biol. 2013;927:51-60.
doi: 10.1007/978-1-62703-038-0_6
PubMed Abstract
PMID: 22992903
UroToday.com Male Infertility & Reproduction Section
