Varicocele is a pathologic enlargement of the pampiniform venous plexus within the spermatic cord, a condition that is a common cause of impaired sperm production and decreased quality of sperm.
While varicocele is the most common surgically correctable risk factor for male infertility, not all males with varicocele experience infertility. In fact, most men with varicocele have normal spermatogenesis. Despite its prevalence, the molecular mechanisms of varicocele and its effect on testicular function are yet to be completely understood. We postulate that men with varicocele-associated infertility could have preexisting genetic lesions or defects in molecular mechanisms that make them more susceptible to varicocele-mediated testicular injury affecting spermatogenesis.
Written by:
Sheehan MM, Ramasamy R, Lamb DJ. Are you the author?
Department of Urology, Weill Cornell Medical College, New York, NY, USA.
Reference: J Assist Reprod Genet. 2014 Mar 19. Epub ahead of print.
doi: 10.1007/s10815-014-0200-9
PubMed Abstract
PMID: 24643631
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