Is there a line between ethics and market competition? Lights and shades of the withdrawal of collagenase treatment for Peyronie's disease.

Peyronie's disease treatments is changing again due the interruption of Xiapex® distrubution in Europe. There are many reasons that can be referred to this event. In this editorial we would like to shed light on the current cost items relating to treatment with collagenase clostridium histolyticum (CCH). The inaccessibility of the drug has seen both an increase in surgery for the treatments of both PD and Dupuytren's disease and an interruption of therapies in patients who had not completed their therapeutic cycle. Considering the aforementioned concerns, we would like to invite researchers dealing with PD to conduct studies with the available CCH products in collaboration with the drug companies in order to give again an efficacious treatment for PD.

International journal of impotence research. 2021 Sep 22 [Epub]

Andrea Cocci, Giorgio Ivan Russo, Juan Ignacio Martinez-Salamanca, David Ralph, Rados Djinovic, Ege Can Şerefoğlu, Nicola Mondaini

Department of Urology and Andrology, University of Florence, Florence, Italy., Urology Section, University of Catania, Catania, Italy. giorgioivan1987@gmail.com., Department of Urology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain., Departments of Andrology, University College London Hospitals, London, UK., Sava Perovic Foundation, Center for Genito-Urinary Reconstructive Surgery, Belgrade, Serbia., Department of Urology, Biruni University School of Medicine, Istanbul, Turkey., Villa Donatello, Private Hospital, Florence, Italy.