Oxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body that can cause tissue damage. Oxidative stress has a significant involvement in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and male infertility. CP/CPPS is a major risk factor for male infertility due to generation of excessive ROS that damage sperm DNA, lipids, and proteins, resulting in compromised vitality and decreased sperm motility. Here we present a comprehensive review of oxidative stress relevance in CP/CPPS and male infertility, and embody the protective effects of antioxidants against ROS. An online literature was searched using the following keywords/terms: oxidative stress, ROS, Oxidative stress and chronic prostatitis, oxidative stress and male infertility and antioxidants. Original and review articles, clinical trials, and case reports of human and animal studies published till 2017 were searched using the PubMed and MEDLINE.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jul 05 [Epub ahead of print]
Awais Ullah Ihsan, Farhan Ullahp Khan, Puregmaa Khongorzul, Khalil Ali Ahmad, Muhammad Naveed, Sufia Yasmeen, Yanfang Cao, Abdoh Taleb, Richinandan Maiti, Fahad Akhter, Xiaoqian Liao, Xue Li, Yijie Cheng, Hidayat Ullah Khan, Khurshid Alam, Xiaohui Zhou
Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China., Shanghai Jiao Tong University, School of Pharmacy, 800 Dongchuan Road, Shanghai, 200240, China., Department of Microbiology and Biochemical Pharmacy, School of Life Science, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China., Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Longmian Avenue, 639, Nanjing, Jiangsu 211198, China., State key laboratory of natural medicines, Department of pharmaceutics, China Pharmaceutical University, Nanjing 210009 China., Department of Biochemistry, School of Life Science, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China., Shifa College of Nursing, Shifa Tameer-e-Millate University, Islamabad, 44000, Pakistan., Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China; Department of Surgery, Nanjing Shuiximen Hospital, Nanjing, Jiangsu Province, 211198, China; Zhongda Hospital, Affiliated with Southeast University, Nanjing, Jiangsu Province, 210017, China. Electronic address: .