We report our initial real-world experience with 177Lu-PSMA-617 radioligand therapy. Methods: We performed a retrospective review of patients treated with 177Lu-PSMA-617. Pretreatment PSMA PET, laboratory findings, overall survival, a fall in prostate-specific antigen by 50% (PSA50), and toxicities were evaluated. Results: Ninety-nine patients were included. Sixty patients achieved a PSA50. Seven of 18 (39%) patients who did not meet the TheraP PSMA imaging criteria achieved a PSA50. Nineteen of 31 (61%) patients who did not meet the VISION laboratory criteria achieved a PSA50. Sixty-three patients had a delay or stoppage in therapy, which was due to a good response in 19 patients and progressive disease in 14 patients. Of 10 patients with a good response who restarted treatment, 9 subsequently achieved a PSA50 on retreatment. The most common toxicities were anemia (33%) and thrombocytopenia (21%). Conclusion: At our center, patients who did not meet the TheraP PSMA imaging criteria or the VISION laboratory criteria benefited from 177Lu-PSMA-617 radioligand therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024 Mar 14 [Epub ahead of print]
Abuzar Moradi Tuchayi, Surekha Yadav, Fei Jiang, Sarasa T Kim, Rachelle K Saelee, Amanda Morley, Roxanna Juarez, Courtney Lawhn-Heath, Yingbing Wang, Ivan de Kouchkovsky, Thomas A Hope
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California; and., Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California., Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California; .