OBJECTIVE: To investigate the impact of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on sperm DNA fragmentation and nucleoprotein transition.
METHODS: Based on the recommended methods in the WHO Laboratory Manual for the Examination and Processing of Human Semen (5th ed), we conducted routine semen analysis for 65 CP/CPPS patients and 30 healthy men. We also analyzed the results of papanicolaou staining, sperm DNA fragmentation and sperm nucleoprotein transition.
RESULTS: Compared with the healthy control males, the CP/CPPS patients showed significant decreases in sperm concentration ([134.05 +/- 99.80] vs [94.75 +/- 92.07]) x 10(6)/ml, P < 0.05), the percentage of morphologically normal sperm ([7.26 +/- 2.28] vs [5.61 +/- 3.40]%, P < 0.05) and sperm progressive motility ([59.18 +/- 16.06] vs [47.68 +/- 17.62]%, P< 0.05), but dramatic increases in sperm DNA fragmentation ([22.92 +/- 11.51] vs (43.58 +/- 17.07%, P< 0.01) and sperm nucleoprotein transition ((23.26 +/- 5.97) vs [32.14 +/- 8.79]%, P< 0.01).
CONCLUSION: CP/CPPS significantly reduces sperm quality and male fertility.
Written by:
Hu YY, Cao SS, Lü JQ. Are you the author?
Center of Reproductive Medicine, The Second Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325000, China.
Reference: Zhonghua Nan Ke Xue. 2013 Oct;19(10):907-11.
PubMed Abstract
PMID: 24218945
Article in Chinese.
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