Purpose: To investigate the relationship between human papillomavirus (HPV) infection and prostatitis-related symptoms.
Materials and Methods: All young heterosexual patients with prostatitis-related symptoms attending the same Center from January 2005 to December 2010 were eligible for this case-control study. Sexually active asymptomatic men were considered as the control group. All subjects underwent clinical examination, Meares-Stamey test and DNA-HPV test. Patients with prostatitis-related symptoms and asymptomatic men were compared in terms of HPV prevalence. Moreover, multivariable Cox proportional hazards regression analysis was performed to determine the association between HPV infection and prostatitis-related symptoms.
Results: Overall, 814 out of 2,938 patients (27.7%) and 292 out of 1,081 controls (27.0%) proved positive to HPV. The HPV genotype distribution was as follows: HR-HPV 478 (43.3%), PHR-HPV 77 (6.9%), LR-HPV 187 (16.9%) and PNG-HPV 364 (32.9%). The most common HPV genotypes were: 6, 11, 16, 26, 51, 53 and 81. No difference was found between the two groups in terms of HPV infection (OR 1.03; 95% CI 0.88-1.22; p = 0.66). We noted a statistically significant increase in HPV infection over the period 2005 to 2010 (p < 0.001) in both groups. Moreover, we found a statistically significant increase in HPV 16 frequency from 2005 to 2010 (p = 0.002).
Conclusions: This study highlights that prostatitis-like symptoms are unrelated to HPV infection. Secondary, we highlight the high prevalence of asymptomatic HPV infection among young heterosexual men.
Written by:
Bartoletti R, Cai T, Meliani E, Mondaini N, Meacci F, Addonisio P, Albanese S, Nesi G, Mazzoli S. Are you the author?
Department of Urology, University of Florence, Florence, Italy; Department of Urology, Santa Chiara Regional Hospital, Trento, Italy; Sexually Transmitted Diseases Center, Santa Maria Annunziata Hospital, Florence, Italy; Department of Pathology and Oncology (GN), University of Florence, Florence, Italy.
Reference: Int Braz J Urol. 2014 Mar-Apr;40(2):247-56.
doi: 10.1590/S1677-5538.IBJU.2014.02.16
PubMed Abstract
PMID: 24856493
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